Jaundice during Chlorpromazine Therapy

The Histopathology of Drug‐induced Liver Disease

“…The hypoglycémie action is attributed to stimu lation, production, or release of insulin from beta cells of the islands of Langerhans. 16 ' 72 · 73 Absorbed chlorpropamide is bound to serum albumin and may perhaps be distributed intracellularly. 73 The adverse clinical reactions in some of the patients following the medication of these two drugs are generally similar, as are the pathologic lesions.…”

“…16 This effect appears to be limited to some individuals irrespective of the dosage, while others are able to tolerate much greater amounts with im punity. Ordinarily, time is required to produce this reaction; in addition laboratory animals are usually either not at all or not significantly affected.…”

“…In contrast to the rather drastic action of the "hepatotoxins," there occurs a more subtle alteration of cells as a side effect of some of the more recently introduced therapeutic compounds (indirect hepatotoxicity). 16 This effect appears to be limited to some individuals irrespective of the dosage, while others are able to tolerate much greater amounts with im punity. Ordinarily, time is required to produce this reaction; in addition laboratory animals are usually either not at all or not significantly affected.…”

Hazard in Use of Beaver Ventilator

“…On withdrawal of the drug the jaundice subsided. Jaundice is known occasionally to follow the administration of chlorpromazine (Lemire and Mitchell, 1954;Zatuchni and Miller, 1954;Hartnett, 1955), andHubble (1941). has reported the hepatotoxic action of phenothiazine.…”

Hypersensitivity Reaction From Acetarsol Pessaries

“…Recently, other drugs including chlorpromazine (Boardman, 1954;Zatuchni and Miller, 1954; Lemire and Mitchell, 1955;Movitt et a/., 1955;Gambescia et al, 1956;Stein and Wright, 1956), methyl testosterone (Almaden and Ross, 1954), and thiouracil (Gargill and Lesses, 1945) have been shown to cause a similar variety of jaundice. One of us has experience of another woman, who, following a few oral doses of chlorpromazine to control hyperemesis gravidarum, developed progressive jaundice which has now lasted 8 months.…”