Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

Abstract

Euphopepluanones F − K (1 − 4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5 − 12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1 − 4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway. Graphic Abstract

Chemical Constituents of Euphorbia stracheyi Boiss (Euphorbiaceae)

“…Euphorbia plants are known for their irritant milky latex [ 27 ] and characteristic and chemically diverse diterpenoids. Among the macrocyclic and polycyclic diterpenoids from Euphorbia , jatrophane types are the most common [ 28 , 29 , 30 , 31 ]. To date, the diterpenoids reported from E. stracheyi have included ent -kaurane, ent -abietane, ent -atisane, ent -isopimarane, labdane, tigliane, lathyrane, and ingenane-type diterpenoids [ 10 , 11 , 12 , 13 , 14 ], but no jatrophanes were isolated from the species.…”