Jatrophane diterpenoids from Euphorbia peplus

Neurotrophic Natural Products: Chemistry and Biology

“…[269] Deoxygedunin ( 286 ), a natural product isolated from Indian neem trees ( Azadirachta indica ), was found to act as a BDNF mimic and exhibited TrkB activation in rat hippocampal neurons at nanomolar concentrations. [203] Kansuinin E ( 287 ), [270] a macrocyclic jatrophane diterpene, [270,271] was found to promote neurotrophic activity, presumably through TrkA activation. [271c] A related study has also suggested that activation of cyclooxygenase plays an essential role in NGF synthesis.…”

Perspectives in Cancer Chemotherapy, in vitro and in vivo Experiments

“…Linear correlation was found between the toxicity and increased accumulation of doxorubicin however the cells were exposed to higher concentration of Euphorbia species have been used in traditional medicine in many countries to treat cancer and warts (140). Besides the presence of highly skin-irritant compounds (phorboids) (141,142), Euphorbia species are of further considerable interest owing to a large diversity of structurally unique and non-irritant jatrophane and lathyrane diterpenoid constituents, which have been considered to be potent modulators of MDR (143,144). Our research group previously reported that extracts containing macrocyclic diterpenes may reverse MDR by inhibiting P-gp in human mdr1 gene-transfected mouse lymphoma cells (114)(115)(116)).…”

Isolation and Structure Elucidation of Diterpenes from Euphorbia pannonica, E. esula and E. falcata

“…The molecular formula of EPAN-3 (1) was assigned as C 24 showed the same relative configuration for these compounds.…”

“…In the course of these studies, many diterpene esters of different skeletal types have been isolated. [22][23][24][25][26][27][28][29][30][31][32][33] One part of this programme involved the investigation of Euphorbia pannonica Host., E. esula L. and E. falcata L. The present thesis summarizes the results of these phytochemical works.…”