JASPER: fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression
Joelle Mbatchou,
Mary Sara McPeek
Abstract:Joint association analysis of multiple traits with multiple genetic variants can provide insight into genetic architecture and pleiotropy, improve trait prediction and increase power for detecting association. Furthermore, some traits are naturally high-dimensional, e.g., images, networks or longitudinally measured traits. Assessing significance for multitrait genetic association can be challenging, especially when the sample has population sub-structure and/or related individuals. Failure to adequately adjust… Show more
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