Japanese traditional miso soup attenuates salt-induced hypertension and its organ damage in Dahl salt-sensitive rats

Yoshinaga, Mariko; Toda, Natsuko; Tamura, Yukie; Terakado, Shouko; Ueno, Mai; Otsuka, Kie; Numabe, Atsushi; Kawabata, Yusuke; Uehara, Yoshio

doi:10.1016/j.nut.2011.09.010

Cited by 37 publications

(43 citation statements)

References 17 publications

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“…The Ministry of Health of China reported that people residing in the North-East of China have been shown to consume an average of 18-19 g day À 1 of salt as compared with only 6-7 g day À 1 in Guangdong, 8-9 g day À 1 in Shanghai, and 14-15 g day À 1 in Beijing. A Japanese study showed a dose-response relationship between diastolic BP and salt consumption, 25 and as would be expected, we found a higher prevalence of hypertension in those who reported a high salt intake compared with those with a low The recommended daily consumption of salt for humans is 3-6 g day À 1 . 26 Finally, Jilin Province has a longer winter season, which can prevent people from taking part in as much outdoor sports and physical activities as people in other regions.…”

Section: Discussionsupporting

confidence: 85%

Prevalence of hypertension and associated risk factors in Dehui City of Jilin Province in China

et al. 2014

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To evaluate the prevalence, awareness, treatment and control of hypertension and its risk factors in Dehui City of Jilin Province in China. The study was performed among 3778 subjects (male=1787) in Dehui City, Jilin Province of China. The subjects completed a standard questionnaire, biochemical tests and physical examinations. Logistic regression analyses were used to identify risk factors for hypertension. The prevalence of hypertension was 41.00% in this area. The awareness, treatment and the control of hypertension were 21.82, 15.56 and 1.10%, respectively, with city areas being significantly higher than rural areas. Significant risk factors for hypertension included age, sex, central obesity, alcohol consumption, family history of hypertension, dyslipidemia, education level and type of work. Further analysis showed that diabetes for urban participants and cigarette smoking for rural participants were risk factors but were not statistically significant at the multi-variate level. The prevalence of hypertension in Dehui Ctiy of Jilin Province is higher than in other areas of China. In addition, rates of awareness and treatment of the condition are much lower than in other populations, with the control rate only 1.10%.

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Section: Discussionsupporting

confidence: 85%

Prevalence of hypertension and associated risk factors in Dehui City of Jilin Province in China

et al. 2014

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“…As a result, the blood pressure of the salt-sensitive rat was not increased by miso diet containing 2.3% NaCl, which indicates that miso diet does not to increase blood pressure in salt-sensitive people. Recently, Yoshinaga et al showed that drinking miso soup for a long term attenuated salt-induced hypertension in Dahl salt-sensitive rats given salt equivalent to the content of miso soup, and the results were associated with an attenuation of kidney damage 89 . Salt in miso works in a different manner from NaCl alone on its own in the case of gastric tumors and blood pressure.…”

Section: Protection Against Hypertensionmentioning

confidence: 99%

Beneficial Biological Effects of Miso with Reference to Radiation Injury, Cancer and Hypertension

Watanabe

2013

J Toxicol Pathol

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This review describes effects of miso with reference to prevention of radiation injury, cancer and hypertension with a twin focus on epidemiological and experimental evidence. Miso with a longer fermentation time increased crypt survival against radiation injury in mice. When evaluating different types of miso provided by different areas in Japan, miso fermented for a longer period increased the number of surviving crypts, and 180 days of fermentation was the most significant. Dietary administration of 180-day fermented miso inhibits the development of azoxymethane (AOM)-induced aberrant crypt foci (ACF) and rat colon cancers in F344 rats. Miso was also effective in suppression of lung tumors, breast tumors in rats and liver tumors in mice. The incidence of gastric tumors of groups of rats given NaCl was higher than those of the groups given miso fermented for longer periods. Moreover, the systolic blood pressure of the Dahl male rat on 2.3% NaCl was significantly increased but that of the SD rat was not. However, the blood pressures of the rats on a diet of miso or commercial control diet (MF) did not increase. Even though miso contains 2.3% NaCl, their blood pressures were as stable as those of rats fed commercial diet containing 0.3% salt. So we considered that sodium in miso might behave differently compared with NaCl alone. These biological effects might be caused by longer fermentation periods.

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“…Both products have various components due to fermentation and maturation. In fermentation, nutrients like isoflavones become abundant, and fermented soybean products can prevent diseases such as cancer, high blood pressure, and hypercholesterolemia . Furthermore, these products may delay progression of aging by oxidative stress due to their antioxidative effect .…”

Section: Introductionmentioning

confidence: 99%

Fermented Soybean Suppresses Visceral Fat Accumulation in Mice

Kushida

Okouchi

Iwagaki

et al. 2018

Molecular Nutrition Food Res

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Japanese traditional miso soup attenuates salt-induced hypertension and its organ damage in Dahl salt-sensitive rats

Cited by 37 publications

References 17 publications

Prevalence of hypertension and associated risk factors in Dehui City of Jilin Province in China

Prevalence of hypertension and associated risk factors in Dehui City of Jilin Province in China

Beneficial Biological Effects of Miso with Reference to Radiation Injury, Cancer and Hypertension

Fermented Soybean Suppresses Visceral Fat Accumulation in Mice

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