Japanese-Specific Filaggrin Gene Mutations in Japanese Patients Suffering from Atopic Eczema and Asthma

Abstract

Abbreviations: AE, atopic eczema; CI, confidence interval; Con, healthy control; OR, odds ratio. For combined genotype: asthma+AE, exact P-value of Pearson w 2 -test=0.0122, OR and 95% CI for dominant models (AA vs aX)=7.3692 (1.7715-30.6748); asthmaÀAE, exact P-value of Pearson w 2 -test=0.5563, OR and 95% CI for dominant models (AA vs aX)=1.6124 (0.4979-5.2219); all asthma, exact P-value of Pearson w 2 -test=0.1968, OR and 95% CI for dominant models (AA vs aX)=2.2523 (0.7609-6.6667).www.jidonline.org 2835 R Osawa et al.

Filaggrin Gene Mutations in Asian Races

“…Of asthma patients complicated by AD, 22.2 % carried one or more FLG mutations; 5.9 % of asthma patients without AD carried one or more FLG mutations. It was confi rmed that in Japan there was a strong association between FLG mutations and AD with or without asthma and between FLG mutations and asthma patients who had AD [ 23 ]. However, no association between asthma and FLG mutations was identifi ed.…”

Asthma

“…Particularly the study by Wang et al found that the P478S GG genotype signifi cantly increased the risk of developing asthma in patients with AD, OR = 4.68 (1.37-16.03). Moreover, Osawa and co-workers studied FLG mutations in patients with AD and asthma, respectively, and found an increased risk of asthma in Japanese-specifi c FLG mutation carriers [ 33 ].…”

Molecular Genetic of Atopic Dermatitis : An Update

“…American, (45) Caucasian and Northern-American AD, (2) European and Asian ancestry, (43,(46)(47)(48)(49)(50)(51) Chinese, (52) German, (53) Irish, (43) and Japanese. (54) More than 40 FLG loss-of-function mutations have been described in Europeans and Asians. (43) While in African-American children with AD revealed a total of 289 variants in FLG, 107 variants in FLG2, 339 variants in HRNR, 4 variants in RPTN, 37 variants in CRNN, 88 variants in TCHH, and 14 variants in TCHHL1.…”