Japanese Multicenter Research of COVID-19 by Assembling Real-world Data: A Study Protocol

Tagami, Takashi; Endo, Akira; Hayakawa, Mineji; Ogura, Takahiro; Hirayama, Atsushi; Yasunaga, Hideo

doi:10.37737/ace.22012

Cited by 11 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The J-RECOVER study was a retrospective multicenter observational study conducted between January and September 2020 in Japan. The design, data collection methods, and protocols for the J-RECOVER study have been reported in detail previously [ 13 ]. This study was approved by the institutional ethics committee of each participating institution, with a waiver for informed consent to protect participant anonymity.…”

Section: Methodsmentioning

confidence: 99%

“…The DPC system is a comprehensive evaluation system for medical fees for acute inpatient care. Data were claimed to have been created and stored electronically at each facility under a comprehensive payment system based on DPC [ 13 , 14 ]. DPC data included sex, birth date, the main purpose of care during hospitalization, admission date, discharge date, patient transfer, route of admission, hospital referral or outpatient department admission, scheduled or emergency care admission, ambulance transport, discharge destination, and discharge outcome.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between institutional ventilated COVID-19 case volume and in-hospital death: A multicenter cohort study

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background The volume-outcome relationship in patients with severe Coronavirus disease 2019 (COVID-19) is unclear and is important for establishing a system for the medical care of severe COVID-19. This study aimed to evaluate the association between institutional case volume and outcomes in patients with ventilated COVID-19. Methods We analyzed patients with severe COVID-19 on ventilatory control aged > 17 years who were enrolled in the J-RECOVER study, which is a retrospective multicenter observational study conducted between January 2020 and September 2020 in Japan. Based on the ventilated COVID-19 case volume, the higher one-third of institutions were defined as high-volume centers, the middle one-third as middle-volume centers, and the lower one-third as low-volume centers. The primary outcome measure was in-hospital mortality during hospitalization due to COVID-19. Multivariate logistic regression analysis for in-hospital mortality and ventilated COVID-19 case volume was performed after adjusting for multiple propensity scores and in-hospital variables. To estimate the multiple propensity score, we fitted a multinomial logistic regression model, which fell into one of the three groups based on patient demographics and prehospital factors. Results We analyzed 561 patients who required ventilator management. In total, 159, 210, and 192 patients were admitted to low-volume (36 institutions, < 11 severe COVID-19 cases per institution during the study period), middle-volume (14 institutions, 11–25 severe cases per institution), and high-volume (5 institutions, > 25 severe cases per institution) centers, respectively. After adjustment for multiple propensity scores and in-hospital variables, admission to middle- and high-volume centers was not significantly associated with in-hospital death compared with admission to low-volume centers (adjusted odds ratio, 0.77 [95% confidence interval (CI): 0.46–1.29] and adjusted odds ratio, 0.76 [95% CI: 0.44–1.33], respectively). Conclusions There may be no significant relationship between institutional case volume and in-hospital mortality in patients with ventilated COVID-19.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Relationship between institutional ventilated COVID-19 case volume and in-hospital death: A multicenter cohort study

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…The J-RECOVER study was a retrospective multicenter observational study conducted in Japan between January and September 2020. The design, data collection methods, and protocols of the J-RECOVER study have been previously reported in detail 22 . The current study was performed in accordance with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…The DPC system is comprehensively evaluated for acute inpatient care costs. Administrative billing data have been created and stored electronically at each institution under a comprehensive payment system based on DPC 22 , 23 . DPC data included sex, date of birth, the primary purpose of care during hospitalization, date of admission, date of discharge, transportation of the patient, route of admission, hospital referral or outpatient department admission, scheduled or emergency care admission, emergency ambulance transport, discharge destination, and the outcomes of discharge.…”

Section: Methodsmentioning

confidence: 99%

Relationship between institutional intensive care volume prior to the COVID-19 pandemic and in-hospital death in ventilated patients with severe COVID-19

Amagasa

Kashiura

Yasuda

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

We aimed to evaluate the association between ICU patient volume before the COVID-19 pandemic and the outcomes of ventilated COVID-19 patients. We analyzed ventilated patients with COVID-19 aged > 17 years and enrolled in the J-RECOVER study, a retrospective multicenter observational study conducted in Japan between January and September 2020. Based on the number of patients admitted to the ICU between January and December 2019, the top third institutions were defined as high-volume centers, the middle third ones as middle-volume centers, and the bottom third ones as low-volume centers. The primary outcome measure was in-hospital mortality. Multivariate logistic regression analysis for in-hospital mortality and ICU patient volume was performed after adjusting for multiple propensity scores. Among 461 patients, 158, 158, and 145 patients were admitted to low-volume (20 institutions), middle-volume (14 institutions), and high-volume (13 institutions) centers, respectively. Admission to middle- and high-volume centers was not significantly associated with in-hospital death compared with admission to low-volume centers (adjusted odds ratio, 1.11 [95% confidence interval (CI): 0.55–2.25] and adjusted odds ratio, 0.81 [95% CI: 0.31–1.94], respectively). In conclusion, institutional intensive care patient volume prior to the COVID-19 pandemic was not significantly associated with in-hospital death in ventilated COVID-19 patients.

show abstract

“…These data are generated, compiled, and ultimately submitted to the Ministry of Health, Labour, and Welfare. 54 , 55 Leveraging DPC data could streamline the data collection and analysis processes. Some data points currently inputted manually into the OHCA Registry could be derived from DPC data.…”

Section: Limitations and Challengesmentioning

confidence: 99%

Overview and future prospects of out-of-hospital cardiac arrest registries in Japan

Okada,

Nakagawa,

Tanaka

et al. 2024

Resuscitation Plus

Self Cite

View full text Add to dashboard Cite

Japanese Multicenter Research of COVID-19 by Assembling Real-world Data: A Study Protocol

Abstract: Background:Data on the evaluation of the clinical course of coronavirus disease 2019 (COVID-19) and the efficacy of treatments after hospitalization in Japan are limited.

Cited by 11 publications

References 24 publications

Relationship between institutional ventilated COVID-19 case volume and in-hospital death: A multicenter cohort study

Relationship between institutional ventilated COVID-19 case volume and in-hospital death: A multicenter cohort study

Relationship between institutional intensive care volume prior to the COVID-19 pandemic and in-hospital death in ventilated patients with severe COVID-19

Overview and future prospects of out-of-hospital cardiac arrest registries in Japan

Contact Info

Product

Resources

About