Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells

Simanjuntak, Yogy; Liang, Jian-Jong; Lee, Yi-Ling; Lin, Yi-Ling

doi:10.3389/fmicb.2017.00651

Cited by 47 publications

(60 citation statements)

References 42 publications

(57 reference statements)

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“…JEV can enter human neuronal cells by caveolin-mediated endocytosis ( 115 ), a process that is receptor-independent ( 116 ). Interestingly, JEV has been shown to utilize the dopaminergic signal transduction pathway to increase neuronal susceptibility to infection ( 117 ). Infection of human dopaminergic neuroblastoma cells in vitro leads to increased levels of secreted dopamine and activation of the phospholipase C cascade.…”

Section: Japanese Encephalitis Virusmentioning

confidence: 99%

Flavivirus Receptors: Diversity, Identity, and Cell Entry

et al. 2018

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Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than seventy small, positive-sense, single-stranded RNA viruses, which are responsible for a spectrum of human and animal diseases ranging in symptoms from mild, influenza-like infection to fatal encephalitis and haemorrhagic fever. Despite genomic and structural similarities across the genus, infections by different flaviviruses result in disparate clinical presentations. This review focusses on two haemorrhagic flaviviruses, dengue virus and yellow fever virus, and two neurotropic flaviviruses, Japanese encephalitis virus and Zika virus. We review current knowledge on host-pathogen interactions, virus entry strategies and tropism.

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Section: Japanese Encephalitis Virusmentioning

confidence: 99%

Flavivirus Receptors: Diversity, Identity, and Cell Entry

et al. 2018

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“…The current study showed that the effect of AT1R on the behavioral effects of METH was associated with the changes in CREB and PLCb, along with the altered activity of D2R. There has been growing evidence about the interaction between D2R and Reduced inositol monophosphate level, which indicated lower activity of PLC, was evident in cells with D2R knockdown (Simanjuntak et al, 2017). Motor skill learning deficits induced by the D2R antagonist raclopride were prevented by the coadministration of the PLC agonist m-3m3fbs (Rioult-Pedotti et al, 2015).…”

Section: Discussionmentioning

confidence: 57%

Inhibition of Methamphetamine Self-Administration and Reinstatement by Central Blockade of Angiotensin II Receptor in Rats

Pan

et al. 2019

J Pharmacol Exp Ther

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The molecular mechanism and treatment of methamphetamine (METH) use disorder remain unclear. The current study aimed to investigate the role of central angiotensin II receptor (ATR) in drug taking and seeking behavior associated with METH use disorder. The effect of an ATR type 1 (AT1R) antagonist, candesartan cilexetil, on the reinforcing and motivational effects of METH was first assessed using the animal model of METH self-administration (SA) and reinstatement. The levels of dopamine D2 receptor (D2R) and AT1R were subsequently examined. Furthermore, the present study determined the expression of microRNAs (miRNAs) by comparing METH SA, METH-yoked, and Saline-yoked groups. The target miRNAs were further overexpressed in the nucleus accumbens (NAc) via a lentivirus vector to investigate the effects of target miRNAs on METH SA maintained under a fixed ratio 1, progressive ratio, and cue/drug reinstatement of METH SA. The potential role of the AT1R-PLCb-CREB signaling pathway was finally investigated. The results suggest that AT1R blockade effectively reduced METH SA and reinstatement, in conjunction with the counter-regulation of D2R and AT1R. A total of 17 miRNAs targeting Ang II in NAc were found to be associated with the voluntary intake of METH. Furthermore, overexpression of specific miR-219a-5p targeting AT1R-regulated METH SA and reinstatement. The AT1R-PLCb-CREB signaling pathway was found to be associated with the effect of AT1R on the drug-taking and drug-seeking behavior involving METH use disorder.Both yoked-METH SA (yoked-METH) and yoked-Saline groups were tested simultaneously with the METH SA group in different conditions. Either a yoked-METH or a yoked-Saline rat was paired with one METH SA rat. Yoked-METH rats received the intravenous infusions of METH at the same dose, number, and rate as the METH SA group. The yoked-Saline group received the intravenous infusions of saline at the same number and rate as the METH SA group. The nose-pokes by the yoked rats were recorded but had no programmed consequences. Cue-and Drug-Induced Reinstatement of METH SAAfter METH SA, the animals were subjected to extinction for 7 days. During the extinction phase, the animals were placed in chambers, AT1R Blockade of Methamphetamine Self-Administration in Rats

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“… 2 19 In study of patients suffering for MERS, neurological manifestation was also reported in few patients. 20 21 So, it is quite imperative to presume that the current pandemic will also have patients presenting with different neurological manifestations. Some of these manifestations will be specifics such as cerebrovascular accidents, seizures, meningitis, and encephalitis, whereas majority will have nonspecific symptoms such as confusion, dizziness, headache, and myalgia.…”

Section: Discussionmentioning

confidence: 99%

Neurological Involvement in COVID-19 Patients: A Narrative Review

Yadav

Srivastava

Bajpai

et al. 2020

JNRP

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Background Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belonging to the coronavirus family. The primary target of SARS-CoV-2 is peripheral mucosal cells of respiratory tract. Recent days have seen few cases where virus has affected extrapulmonary organ such as nervous system. Materials and Methods The present study was a narrative review done using techniques of systemic review, that is, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Electronic databases such as PubMed (Medline) and Google Scholar were searched systematically for published article from December 1, 2019 to June 5, 2020. A total of 189 articles were initially selected by the authors. A final list of 17 articles was prepared and following information were extracted from selected studies: study design, main result, and limitations of the study. Results Majority of these article were descriptive studies describing spectrum of signs and symptoms among admitted patients. In majority of these studies, patients have developed symptoms suggestive of neurological involvement. Most common central nervous system symptoms reported were headache, followed by dizziness and confusion. Similarly, the most common peripheral nervous system involvement was loss of taste and smell. Conclusion The present study concludes that there are enough evidences to prove that SARS-CoV-2 infection affects both central and peripheral nervous system. Various mechanisms are proposed to explain the pathophysiology of neurological manifestations in COVID-19-positive patients that needs to be established and verified.

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Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells

Cited by 47 publications

References 42 publications

Flavivirus Receptors: Diversity, Identity, and Cell Entry

Flavivirus Receptors: Diversity, Identity, and Cell Entry

Inhibition of Methamphetamine Self-Administration and Reinstatement by Central Blockade of Angiotensin II Receptor in Rats

Neurological Involvement in COVID-19 Patients: A Narrative Review

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