Japanese cedar pollinosis in Tokyo residents born after massive national afforestation policy

Urashima, Mitsuyoshi; Asaka, Daiya; Endo, Takumi; Omae, Sachiko; Sugimoto, Naoki; Takaishi, Shinya; Mitsuyoshi, Ryoto; Nakayama, Tsuguhisa; Nagakura, Hitoshi; Endo, Takuro; Akutsu, Taisuke; Tachimoto, Hiroshi; Kojima, Hiromi

doi:10.1111/all.13575

Cited by 19 publications

(9 citation statements)

References 2 publications

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“…1,2 Recent studies have found different allergens to be prevalent in different regions. For example, birch and grass pollen are the two most common allergens in Denmark, 3 Japanese cedar pollen (JC) is most common in Japan, 4,5 and artemisia pollen is the main allergen in northern China. 6 In some regions, ragweed is the most common sensitizing allergen.…”

Section: Environmental Fac Tor Smentioning

confidence: 99%

“…For instance, the prevalence of AR is high and on the rise in Japan and Inner Mongolia in China. 5,12,13 The prevalence of allergic diseases has also been found to be different in urban and rural areas. For example, a more recent study assessing the relationship between environmental and dietary factors and allergic diseases in urban and rural children in South Africa showed that exposure to farm animals during pregnancy had a protective effect against allergic outcomes in infants and their mothers in rural populations.…”

Section: Environmental Fac Tor Smentioning

confidence: 99%

“…Moreover, as differences in the environment and the allergens in different regions are likely to impact the clinical diagnosis of patients with AR, 11 this may consequently lead to differences in AR prevalence. For instance, the prevalence of AR is high and on the rise in Japan and Inner Mongolia in China 5,12,13 …”

Section: Environmental Factorsmentioning

confidence: 99%

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Advances and novel developments in allergic rhinitis

Meng

Wang

Zhang

2020

Allergy

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Allergic rhinitis (AR) is an upper airway disease with high prevalence in the world, and therefore needs to be thoroughly investigated and treated accordingly. Although the mechanisms underlying the pathology and treatment of AR have been widely studied, many aspects of AR are still unclear and warrant further investigations. The purpose of the present review was therefore to report recently published papers, which highlight the novel mechanisms and treatments of AR. These include role of environment, important proteins and cells, and some other factors in the pathogenesis of AR; as well as the role of immunotherapy and biologics in the treatment of AR.

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Section: Environmental Fac Tor Smentioning

confidence: 99%

Section: Environmental Fac Tor Smentioning

confidence: 99%

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Advances and novel developments in allergic rhinitis

Meng

Wang

Zhang

2020

Allergy

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“…Currently, more than 30% of the Japanese population suffers from JC pollinosis between February and April each year, which is a kind of a national affliction [3]. In our recent epidemiological study, we demonstrated that the prevalence of JC pollinosis in the Tokyo metropolitan area reaches 45.6% [4], resulting in a strong social demand for an effective treatment.…”

Section: Introductionmentioning

confidence: 99%

Immunological and Symptomatic Effects of Oral Intake of Transgenic Rice Containing 7 Linked Major T-Cell Epitopes from Japanese Cedar Pollen Allergens

Endo

Asaka

Saito

et al. 2020

Int Arch Allergy Immunol

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Background: A rice-based peptide vaccine containing 7 linked human predominant T-cell epitopes (7Crp) derived from Japanese cedar (JC) pollen allergens, Cry j 1 and Cry j 2, was developed. Here, we examined the efficacy and safety of this transgenic rice in JC pollinosis patients. Methods: Transgenic rice (5, 20, and 80 g) was administered orally. We measured the T-cell proliferative activity against 7Crp, Cry j 1, and Cry j 2; the cytokine expression levels; and specific IgE and IgG4 production levels. In addition, the symptom and medication scores were monitored during the pollen season, and quality of life (QOL) was evaluated. Results: T-cell proliferative activities to Cry j 1, Cry j 2, and 7Crp were significantly depressed in a dose-dependent manner. Oral intake of 80 g transgenic rice for 20 weeks resulted in significant suppression of allergen-specific T-cell proliferation with downregulation of IL-13 and upregulation of IL-10 levels but no changes to specific IgE and IgG4 levels. The QOL symptom scores for allergic rhinitis were not significantly improved. Conclusions: Allergen-specific T-cell responses were significantly reduced by oral intake of transgenic rice in a dose-dependent manner. However, neither medication score nor QOL symptom scores could be improved during the JC pollen season with oral intake of transgenic rice for 20 weeks.

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“…Seasonal allergic rhinitis has become a global health problem because of its high worldwide prevalence (10%-30%). 4 The prevalence of Japanese cedar pollinosis (JCP), a representative seasonal allergic rhinitis in Japan, has reached almost 50%, 2,5 and JCP is now called a folk disease in Japan.…”

mentioning

confidence: 99%