Janus kinase inhibitors for the use of alopecia areata: A promising therapeutic of the future

Updyke, Katelyn M

doi:10.1111/dth.12556

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An emerging therapeutic target for AA is the Janus kinase (JAK) and signal transducers and activators of transcription (STAT) pathway. JAK inhibitors have recently attracted great interest in the literature, 1,[16][17][18] and their use in AA will be discussed further in this review.…”

Section: Introductionmentioning

confidence: 99%

The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature

et al. 2019

View full text Add to dashboard Cite

Alopecia areata (AA) is a chronic, immune-mediated disorder that targets hair follicle epithelium, thereby restricting hair growth in localized patches. Although several therapies for AA have been tested, responses with traditional therapies have been limited. In recent years, numerous reports have been published of patients with AA responding to Janus kinase (JAK) inhibitors. This literature review aims to describe AA pathophysiology, explore how and why JAK inhibitors can be used for AA treatment, and review published case reports, case series, and open-label studies published to date. Pathogenesis of AA includes interactions between genetic, environmental, and immune factors and is mediated by the cytokines interferon-γ and interleukin (IL)-15. JAK inhibition resulting in hair regrowth in some cases supports that AA is associated with the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The emergence of JAK inhibitors for AA therapy is changing the way health care providers think about and treat AA. A mixture of animal model studies and human case studies have reported the use of baricitinib (JAK 1/2), ruxolitinib (JAK 1/2), and tofacitinib (JAK 1/3) for the management of AA. JAK inhibition has shown potential as an effective AA therapy when used in case studies, case series, and open-label trials. Formal clinical trials are ongoing and will yield more definitive conclusions about the safety and efficacy of JAK inhibitors.

show abstract

Section: Introductionmentioning

confidence: 99%