“Janus-Featured” Hydrogel with Antifouling and Bacteria-Releasing Properties

Abstract

Janus-featured" hydrogels with different structure and function for each layer can be particularly important in diverse application. However, very few studies have been conducted on multifunctional Janus-featured hydrogel, and significant challenge for simple, rapid, and efficient fabrication of such hydrogels remains. Herein, Janus-featured poly(N-hydroxyethyl acrylamide) (polyHEAA) hydrogel loaded with modified silica nanoparticle was fabricated by the supergravity method. Silica nanoparticles grafted with poly(3-(dimethyl(4-vinylbenzyl) ammonio) propyl sulfonate) (polyDVBAPS) were first prepared and then introduced into progel of polyHEAA hydrogel. During the formation of the hydrogel, a supergravity resulting from centrifugation was applied, from which silica nanoparticles moved to one side of the hydrogel, forming Janus-featured hydrogels, i.e., a pristine polyHEAA layer and a composite layer. These two layers showed different properties, where the prinstine polyHEAA layer showed excellent antifouling property by resisting the bacteria adsorption (<10 6 cells/cm 2 ) for up to 5 days, and the nanoparticle-loaded hydrogel layer showed excellent bacteria-releasing properties by releasing >94% adherent bacteria upon a simple treatment with 2.0 M NaCl solution for 10 min. Based on its superb biocompatibility and low biotoxicity, we expect that our interesting strategy may provide a new assumption for the fabrication of "Janus featured" hydrogel and hopefully offer reference significance for the design of hydrogel-based wound dressing in the near future.

Hydrogel: Diversity of Structures and Applications in Food Science

“…and function for each layer can be particularly important in diverse applications. [247,[386][387][388][389][390] Figure 8. Illustrations of core-shell-structured hydrogels.…”

Janus particles and motors: unrivaled devices for mastering (bio)sensing

“…This can hamper analytical performance and avoid adequate in vivo operation [ 33 ]. To avoid this, JPs and JMs can be functionalized with external layers such as protein corona, natural proteins [ 34 ], or hydrogels [ 35 ], among others.…”

Novel Salt-Responsive SiO2@Cellulose Membranes Promote Continuous Gradient and Adjustable Transport Efficiency

“…Monodisperse silicon dioxide nanoparticles (SiO 2 NPs) with different diameters were first synthesized by using the traditional Stober method according to our previous work. 33 Briefly, taking 146 nm SiO 2 NPs as an example, 150 mL of ethanol and 14 mL of ammonium hydroxide (25−28%) were premixed for 30 min. After heating to 65 °C, a 35 mL aliquot of a TEOS/ethanol mixture (V 1 /V 2 = 3:4) was added to the system dropwise for 1 h at 300 rpm, and the reaction proceeded for ∼8 h. The obtained homogeneous SiO 2 NPs were then separated by 8000 rpm centrifugation.…”