Janus-Faced Neutrophil Extracellular Traps in Periodontitis

Vitkov, Ljubomir; Hartl, Dominik; Minnich, Bernd; Hannig, Matthias

doi:10.3389/fimmu.2017.01404

Cited by 27 publications

(29 citation statements)

References 78 publications

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“…Neutrophils can also capture bacteria with neutrophil extracellular traps (NETs), which are web-like structures mainly consisting of decondensed chromatin and bactericidal proteins ( 22 , 23 ). Recent studies have shown that NETs are abundantly produced in periodontitis ( 24 , 25 ). During the process of NET activation and release (known as NETosis), DNA-bound histones are citrullinated by the human peptidylarginine deiminases, leading to a change in charge and decondensation of the DNA ( 26 ).…”

Section: Resultsmentioning

confidence: 99%

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

Stobernack

Espina

Mulder

et al. 2018

mBio

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Bacterial pathogens do not only succeed in breaking the barriers that protect humans from infection, but they also manage to evade insults from the human immune system. The importance of the present study resides in the fact that protein citrullination is shown to represent a new bacterial mechanism for immune evasion. In particular, the oral pathogen P. gingivalis employs this mechanism to defuse innate immune responses by secreting a protein-citrullinating enzyme. Of note, this finding impacts not only the global health problem of periodontitis, but it also extends to the prevalent autoimmune disease rheumatoid arthritis, which has been strongly associated with periodontitis, PPAD activity, and loss of tolerance against citrullinated proteins, such as the histone H3.

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Section: Resultsmentioning

confidence: 99%

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

Stobernack

Espina

Mulder

et al. 2018

mBio

View full text Add to dashboard Cite

show abstract

“…As we know, the formation of citrullinated proteins is catalyzed by peptidylarginine deiminase (PAD) enzymes. Porphyromonas gingivalis (P. gingivalis), an oral bacteria that is a crucial factor for periodontitis and express PAD and citrullinated enolase, can mediate citrullination of bacterial and host protein [89]. It has been shown that deletion of the bacterial PAD gene results in complete abrogation of protein citrullination [90].…”

Section: Parodontitis Nets and Anticitrulline Response In Ramentioning

confidence: 99%

Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis

Chen

Wang

et al. 2018

Journal of Immunology Research

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Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by the presence of autoantibodies against citrullinated protein antigens and proinflammatory cytokines which cause chronic synovitis, bone erosion, and eventual deformity; however, the precise etiology of RA is unclear. In the early stage of RA, neutrophils migrate into the articular cavity, become activated, and exert their function in an inflammatory process, suggesting an essential role of neutrophils in the initial events contributing to the pathogenesis of RA. Solid evidence exists that supports the contribution of neutrophil extracellular traps (NETs) to the production of autoantibodies against citrullinated proteins which can trigger the immune reaction in RA. Concurrently, proinflammatory cytokines regulate the neutrophil migration, apoptosis, and NET formation. As a result, the inflammatory neutrophils produce more cytokines and influence other immune cells thereby perpetuating the inflammatory condition in RA. In this review, we summarize the advances made in improving our understanding of neutrophil migration, apoptosis, and NET formation in the presence of an RA inflammatory milieu. We will also discuss the most recent strategies in modulating the inflammatory microenvironment that have an impact on neutrophil function which may provide alternative novel therapies for RA.

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“…Besides their role as a host defense mechanism, NETs play a pivotal role in non-infectious conditions, such as systemic lupus erythematosus ( 6 ), rheumatoid arthritis, cystic fibrosis ( 7 , 8 ), and psoriasis ( 9 ). They are also involved in other pathological processes, such as coagulation disorders, thrombosis ( 10 ), diabetes ( 11 , 12 ), atherosclerosis ( 13 ), vasculitis ( 14 ), wound healing ( 12 ), and periodontitis ( 15 , 16 ). Recently, several studies have investigated the role of NETs in tumors and reported their involvement in cancer immunoediting ( 3 ), progression ( 3 , 17 – 19 ), metastatic spread ( 20 ), and cancer associated thrombosis ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

et al. 2020

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Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to their key role in the neutrophil innate immune response, NETs are also involved in autoimmune diseases, like systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and in other non-infectious pathological processes, as coagulation disorders, thrombosis, diabetes, atherosclerosis, vasculitis, and cancer. Recently, a large body of evidence indicates that NETs are involved in cancer progression and metastatic dissemination, both in animal models and cancer patients. Interestingly, a close correlation between cancer cell recruitment of neutrophils in the tumor microenvironment (Tumor Associated Neutrophils. TANs) and NET formation has been also observed either in primary tumors and metastatic sites. Moreover, NETs can also catch circulating cancer cells and promote metastasis. Furthermore, it has been reported that wake dormant cancer cells, causing tumor relapse and metastasis. This review will primarily focus on the pro-tumorigenic activity of NETs in tumors highlighting their ability to serve as a potential target for cancer therapy.

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Janus-Faced Neutrophil Extracellular Traps in Periodontitis

Cited by 27 publications

References 78 publications

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

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