January 2020 at a glance: translational medicine, predictors of outcome and treatments

Adamo, Marianna; Lombardi, Carlo; Metra, Marco

doi:10.1002/ejhf.1505

Cited by 1 publication

(1 citation statement)

References 22 publications

(31 reference statements)

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“…Although the mechanism underlying the association between a low heart failure hospitalization rate and PH is unclear, one hypothesis is that PH could be an indicator of the well-decongestive status in patients with heart failure. Dehydration is a well-known cause of PH 27 , and a position statement proposed by the European Society of Cardiology considered PH a sign of the euvolemic status in patients with heart failure 28 . Since we did not obtain data regarding changes in body weight, BNP, diuretic response, hemoconcentration, or echocardiographic parameters at admission, we could not evaluate our hypothesis that PH before discharge is associated with decongestion status.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of postural hypotension in hospitalized patients with heart failure

Sunayama

Maeda

Matsue

et al. 2022

Sci Rep

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Although postural hypotension (PH) is reportedly associated with mortality in the general population, the prognostic value for heart failure is unclear. This was a post-hoc analysis of FRAGILE-HF, a prospective multicenter observational study focusing on frailty in elderly patients with heart failure. Overall, 730 patients aged ≥ 65 years who were hospitalized with heart failure were enrolled. PH was defined by evaluating seated PH, and was defined as a fall of ≥ 20 mmHg in systolic and/or ≥ 10 mmHg in diastolic blood pressure within 3 min after transition from a supine to sitting position. The study endpoints were all-cause death and heart failure readmission at 1 year. Predictive variables for the presence of PH were also evaluated. PH was observed in 160 patients (21.9%). Patients with PH were more likely than those without PH to be male with a New York Heart Association classification of III/IV. Logistic regression analysis showed that male sex, severe heart failure symptoms, and lack of administration of angiotensin-converting enzyme inhibitors were independently associated with PH. PH was not associated with 1-year mortality, but was associated with a lower incidence of readmission after discharge after adjustment for other covariates. In conclusion, PH was associated with reduced risk of heart failure readmission but not with 1-year mortality in older patients with heart failure.

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Section: Discussionmentioning

confidence: 99%