Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization.

O'Sullivan, J; McCullough, John E.; Johnson, Janice H.; Bonner, Daniel P.; Clark, Junius C.; Dean, Loretta D.; Trejo, William H.

doi:10.7164/antibiotics.43.913

Cited by 26 publications

(23 citation statements)

References 15 publications

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“…However, further investigation is required to obtain detailed function of LAB in Hong Qu glutinous rice wine. J. lividum was also detected frequently in Hong Qu and Yao Qu, which is a Gram-negative, motile, aerobic bacterium commonly isolated from the microbiota of soils and water of rivers, lakes and springs (Johnson, Tymiak, & Bolgar, 1990;O'sullivan et al, 1990;Rossolini et al, 2001). It is a potential foodborne pathogen and had been reported involving in the spoilage of pasteurized milk (Eneroth, Ahrnè, & Molin, 2000).…”

Section: Discussionmentioning

confidence: 96%

Microbial diversity of traditional fermentation starters for Hong Qu glutinous rice wine as determined by PCR-mediated DGGE

Wang

Zhang

et al. 2012

Food Control

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Section: Discussionmentioning

confidence: 96%

Microbial diversity of traditional fermentation starters for Hong Qu glutinous rice wine as determined by PCR-mediated DGGE

Wang

Zhang

et al. 2012

Food Control

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“…This result might be due to methodological reasons, such as PCR bias. It is known that J. lividum produces the peptide lactone antibiotics Janthinocin A, B and C (O'Sullivan et al, 1990), and in our challenge assays it was found to be weakly antifungal against both fungi.…”

Section: Antifungal Cutaneous Bacteria From Salamandersmentioning

confidence: 92%

Diversity of cutaneous bacteria with antifungal activity isolated from female four-toed salamanders

et al. 2007

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Among the microbiota of amphibian skin are bacteria that produce antifungal compounds. We isolated cutaneous bacteria from the skins of three populations of the nest-attending plethodontid salamander Hemidactylium scutatum and subsequently tested the bacterial isolates against two different fungi (related to Mariannaea elegans and Rhizomucor variabilis) that were obtained from dead salamander eggs. The culturable antifungal bacteria were phylogenetically characterized based on 16S rRNA phylogeny, and belonged to four phyla, comprising 14 bacterial families, 16 genera and 48 species. We found that about half of the antifungal bacterial genera and families were shared with a related salamander species, but there was virtually no overlap at the species level. The proportion of culturable antifungal bacterial taxa shared between two large populations of H. scutatum was the same as the proportion of taxa shared between H. scutatum and Plethodon cinereus, suggesting that populations within a species have unique antifungal bacterial species. Approximately 30% of individuals from both salamander species carried anti-M. elegans cutaneous bacteria and almost 90% of P. cinereus and 100% of H. scutatum salamanders carried anti-R. variabilis cutaneous bacteria. A culture independent method (PCR/DGGE) revealed a shared resident bacterial community of about 25% of the entire resident bacterial community within and among populations of H. scutatum. Thus, the culturable antifungal microbiota was far more variable on salamander skins than was the bacterial microbiota detected by PCR/DGGE. The resident cutaneous antifungal bacteria may play an important role in amphibians' innate defense against pathogens, including the lethal chytrid fungus Batrachochytrium dendrobatidis.

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“…are Gram-negative, motile bacteria that have been isolated from a wide range of habitats including the Antarctic (Mojib et al, 2011), as symbionts of insects (Zhang et al, 2011a) and amphibians (Brucker et al, 2008;Harris et al, 2009), and from plants and the environment (Kang et al, 2007;Kim et al, 2012). Janthinocin A, B and C were isolated in 1990 from a water isolate of Janthinobacterium lividum (O'Sullivan et al, 1990). These macrocyclic decapeptide lactones were shown to have activity equal to or better than vancomycin against a range of Gram-positive aerobes and anaerobes, including MRSA and VRE strains (O'Sullivan et al, 1990).…”

Section: The Genus Janthinobacteriummentioning

confidence: 99%

“…Antibacterial compounds, such as the janthinocins (O'Sullivan et al, 1990) and the antifungal compounds violacein (Pantanella et al, 2007) and jagaricin (Graupner et al, 2012) (Graupner et al, 2012;Pantanella et al, 2007) have been identified from Janthinobacterium species. Janthinobacterium spp.…”

Section: The Genus Janthinobacteriummentioning

confidence: 99%

Antibiotics from neglected bacterial sources

Pidot¹,

Coyne²,

Kloß³

et al. 2014

International Journal of Medical Microbiology

119

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Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization.

Cited by 26 publications

References 15 publications

Microbial diversity of traditional fermentation starters for Hong Qu glutinous rice wine as determined by PCR-mediated DGGE

Microbial diversity of traditional fermentation starters for Hong Qu glutinous rice wine as determined by PCR-mediated DGGE

Diversity of cutaneous bacteria with antifungal activity isolated from female four-toed salamanders

Antibiotics from neglected bacterial sources

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