Jamestown Canyon Virus: Seroprevalence in Connecticut

Mayo, Donald R.; Karabatsos, Nick; Scarano, Frank J.; Brennan, Timothy; Buck, Daniel; Fiorentino, Terry; Mennone, John; Tran, San

doi:10.3201/eid0705.017529

Cited by 29 publications

(14 citation statements)

References 4 publications

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“…In comparison to LACV, however, our JCV cases demonstrated that children were less frequently affected, with no cases in children less than 10 years of age and 63% of cases aged > 40 years. 24–27…”

Section: Discussionmentioning

confidence: 99%

Enhanced Arboviral Surveillance to Increase Detection of Jamestown Canyon Virus Infections, Wisconsin, 2011–2016

Matkovic

Johnson

Staples

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Abstract.Jamestown Canyon virus (JCV), a mosquito-borne Orthobunyavirus (within the California serogroup), can cause severe neuroinvasive disease. According to national data during 2000–2013, 42% of the 31 documented JCV disease cases in the United States were detected in residents from Wisconsin. The Wisconsin Division of Public Health enhanced JCV surveillance by implementing routine use of JCV-specific immunoglobulin M (IgM) antibody testing followed by confirmatory JCV-specific plaque reduction neutralization testing on all patients with suspected cases of arboviral infection who had tests positive for arboviral immunoglobin at commercial laboratories. During 2011–2016, of the 287 Wisconsin specimens tested on the Arbovirus IgM Antibody Panel, 30 JCV cases were identified (26 confirmed and four probable). Twenty-seven (90%) JCV cases were detected after 2013. Among all cases, 17 (56%) were male and the median age was 54 years (range: 10–84 years). Fifteen patients had neuroinvasive disease, including meningitis (n = 9) and meningoencephalitis (n = 6). Although historically considered rare, the relatively high rate (0.12 cases/100,000 population) of diagnosis of JCV infections among Wisconsin residents during 2013–2016 compared with that in previous years suggests occurrence is widespread throughout Wisconsin and historically may have been under-recognized. This study aims to raise awareness of JCV infection for differential diagnosis among the arboviral diseases. Improved and timely diagnosis of arboviral disease is important in that it will provide more information regarding emerging infections and promote preventive measures to avoid mosquito-borne exposure and infection among residents of and visitors to affected areas.

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Section: Discussionmentioning

confidence: 99%

Enhanced Arboviral Surveillance to Increase Detection of Jamestown Canyon Virus Infections, Wisconsin, 2011–2016

Matkovic

Johnson

Staples

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…72 A recent report of a Jamestown Canyon virus infection in Montana underscores continued low-level transmission in the northern continental United States. 73 …”

Section: Bunyaviridaementioning

confidence: 99%

Arbovirus Infections

Beckham¹,

Tyler²

2015

CONTINUUM: Lifelong Learning in Neurology

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Purpose of Review Arbovirus (arthropod-borne virus) infections are increasingly important causes of neurologic disease in the United States through both endemic transmission and travel-associated infections. This article reviews the major arbovirus infections that can cause neurologic disease likely to be encountered in the United States. Recent Findings West Nile virus continues to be an important cause of epidemic encephalitis, while emerging arbovirus infections such as dengue and chikungunya have rapidly expanded their geographic distribution. As emerging arboviruses expand in new geographic regions, neurologic abnormalities are reported in new patient populations. Summary Emerging arbovirus infections are increasingly important causes of neurologic disease throughout the world and in the United States. While no US Food and Drug Administration (FDA)–approved therapy is yet available for these infections, prompt recognition and diagnosis from the consulting neurologist will ensure appropriate supportive care for the patient.

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“…Confirmatory testing includes anti-JCV IgM antibody screening, with a reflex to PRNT if reactive (3). Seroprevalence studies have demonstrated the presence of neutralizing antibodies to JCV at various rates (3.9 to 17.6% in two studies [5,6]), which suggests that mild or asymptomatic infections occur.…”

Section: Discussionmentioning

confidence: 99%

The Brief Case: A 10-Year-Old Girl with Meningoencephalitis

et al. 2018

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A previously healthy, fully immunized 10-year-old girl from Minnesota presented in July with a 1-week history of headaches, dizziness, myalgias, pharyngitis, and fever and a 1-day history of double vision, unsteady gait, and slurred speech. Her symptoms began approximately 4 days after returning from a family vacation to northern Wisconsin, where she had spent significant time outdoors and had exposure to mosquitoes. Upon evaluation in the emergency department, she was afebrile with normal vital signs. She was oriented but drowsy, demonstrated dysarthric (i.e., slurred) speech and dysmetria (i.e., lack of coordination of movement), and had trouble walking. A complete blood count showed a hemoglobin of 13.3 g/dl (normal range, 12.0 to 14.5 g/dl), white blood cell count of 9.1 ϫ 10 9 /liter (3.4 ϫ 10 9 to 10.8 ϫ 10 9 /liter), and platelet count of 124 ϫ 10 9 /liter (150 ϫ 10 9 to 450 ϫ 10 9 /liter). Reactive lymphocytes (i.e., large, antigen-stimulated cells) were observed on a peripheral blood smear. A basic metabolic panel and liver function tests were within normal limits, and a urine drug screen was negative. A cranial computed tomography (CT) scan was normal, while magnetic resonance imaging (MRI) of the brain with intravenous contrast showed subtle signs of inflammation (leptomeningeal enhancement concentrated in the brainstem, cortical, limbic, and deep gray structures), which is a pattern that can be seen with viral meningoencephalitis (Fig. 1). An electroencephalogram was performed, which showed no lateralized periodic discharges or other abnormalities. Laboratory studies included serologic testing for herpes simplex virus 1 and 2 (HSV1/2), Bartonella henselae, B. quintana, and Lyme disease, all of which were negative. A tick-borne disease real-time PCR panel targeting Anaplasma phagocytophilum, Ehrlichia species, Babesia species, and Borrelia miyamotoi, performed on whole blood, was negative. A lumbar puncture was performed, and cerebrospinal fluid (CSF) showed a total nucleated cell count of 219/l, with a differential of 44% lymphocytes, 44% neutrophils, and 12% monocytes. In addition, the CSF showed a normal glucose level of 53 mg/dl (normal range, 40 to 70 mg/dl) and an elevated protein level of 95 mg/dl (12 to 60 mg/dl). Gram stain of the CSF showed white blood cells but no organisms. Bacterial culture of the CSF grew one colony of Corynebacterium species and Lactobacillus gasseri (1ϩ growth), both of which were interpreted as contaminants. Further testing on CSF included real-time PCR for cytomegalovirus, enterovirus, Epstein-Barr virus, HSV1/2, West Nile virus (WNV), varicella-zoster virus (VZV), and free-living amoe

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Jamestown Canyon Virus: Seroprevalence in Connecticut

Cited by 29 publications

References 4 publications

Enhanced Arboviral Surveillance to Increase Detection of Jamestown Canyon Virus Infections, Wisconsin, 2011–2016

Enhanced Arboviral Surveillance to Increase Detection of Jamestown Canyon Virus Infections, Wisconsin, 2011–2016

Arbovirus Infections

The Brief Case: A 10-Year-Old Girl with Meningoencephalitis

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