James Hardy and the first heart transplant

Morris, T

doi:10.1016/s0140-6736(17)31499-x

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Solid organ xenotransplantation is not a new concept: primate-to-human kidney, heart or liver transplants were performed from the 1960s until the 1980s [23][24][25][26][27][28][29], but generally failed soon after surgery. For example, a chimpanzee heart transplant failed in 1964 because of size mismatch between the primate and the adult [28]; chimpanzee and baboon xenotransplants conducted by Christian Barnard were unsuccessful, possibly because of heterotopic positioning of the xenotransplants [28].…”

Section: Previous Attemptsmentioning

confidence: 99%

Organ transplants of the future: planning for innovations including xenotransplantation

et al. 2021

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The future clinical application of animal-to-human transplantation (xenotransplantation) is of importance to society as a whole. Favourable preclinical data relevant to cell, tissue and solid organ xenotransplants have been obtained from many animal models utilizing genetic engineering and protocols of pathogen-free husbandry. Findings have reached a tipping point, and xenotransplantation of solid organs is approaching clinical evaluation, the process of which now requires close deliberation. Such discussions include considering when there is sufficient evidence from preclinical animal studies to start first-in-human xenotransplantation trials. The present article is based on evidence and opinions formulated by members of the European Society for Organ Transplantation who are involved in the Transplantation Learning Journey project. The article includes a brief overview of preclinical concepts and biology of solid organ xenotransplantation, discusses the selection of candidates for first-in-human studies and considers requirements for study design and conduct. In addition, the paper emphasizes the need for a regulatory framework for xenotransplantation of solid organs and the essential requirement for input from public and patient stakeholders.

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Section: Previous Attemptsmentioning

confidence: 99%

Organ transplants of the future: planning for innovations including xenotransplantation

et al. 2021

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“…In addition a few more American surgeons were preparing for the surgery. On 23 rd January 1964 Dr Thomas Hardy at Mississippi transplanted the failing heart of a terminally ill patient with that of a donor chimpanzee 8 . His attempt failed and turned into a medical and media disaster with harsh criticism from various corners.…”

Section: Christiaan Neethling Barnard Was Born In a Small Town Of Beamentioning

confidence: 99%

The Hero the First Human Heart Transplantation

Hosain¹

2020

Cardiovasc. j.

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“…A small number of organ transplants are performed annually 1 in South Africa, and the demand for organs far exceeds their supply. Although it has a prominent transplant history, such as the first heart transplant by Christiaan Barnard 2 and the first HIV positive to HIV-positive living donor kidney transplant program, 3 South Africa still faces very low donor rates as compared to other parts of the world. 4…”

Section: Introductionmentioning

confidence: 99%