Jakyak-gamcho-tang, a decoction of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma, ameliorates dexamethasone-induced muscle atrophy and muscle dysfunction

Unveiling the Potential of Nelumbo nucifera-Derived Liensinine to Target The Myostatin Protein and to Counteract Muscle Atrophy

“…Moreover, oral administration of 100 mg/kg Jakyak-gamcho-tang (JGT, a decoction of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma) failed to restore motor coordination in mice with muscle atrophy induced by DEX at a dose of 25 mg/kg. Treatment with a higher concentration of JGT (400 mg/kg) resulted in a 63.5% recovery of motor coordination compared with normal control mice . In the present study, a much lower concentration of LIE (10 mg/kg body weight) led to a notably higher degree of motor coordination recovery, reaching 75.8% of normal control mice.…”

“…Treatment with a higher concentration of JGT (400 mg/ kg) resulted in a 63.5% recovery of motor coordination compared with normal control mice. 43 In the present study, a much lower concentration of LIE (10 mg/kg body weight) led to a notably higher degree of motor coordination recovery, reaching 75.8% of normal control mice. These findings underscore the substantial efficacy of LIE in restoring muscle health in in vivo experiments.…”