JAK-STAT signaling pathway inhibition: a role for treatment of various dermatologic diseases

Kahn, Jared S.; Deverapalli, Sandhya; Rosmarin, David

doi:10.12788/j.sder.2018.041

Cited by 16 publications

(13 citation statements)

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“…Some genes targeted by deregulated plasma miRNAs were associated with angiogenesis (i.e., VEGF pathway) and adaptive and innate immune responses, and proinflammatory genes, such as IL4R, were also identified. In addition, the JAK/STAT pathway, which is related to autoimmune diseases [44,46], such as psoriasis [45,47,48], was also observed. Plasma miRNA target genes play a role in apoptosis, which is associated with psoriasis pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Plasma MicroRNA Expression Profiles in Psoriasis

Xiao

Liu

Wang

et al. 2020

Journal of Immunology Research

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Background. Psoriasis is an immune-mediated inflammatory chronic skin disease characterized by chronic inflammation in the dermis, parakeratosis, and excessive epidermal growth. MicroRNAs (miRNAs) are key regulators of immune responses. Although differential expression of miRNAs has been reported in certain inflammatory autoimmune diseases, their role in psoriasis has not been fully illuminated. Our aims were to confirm plasma miRNA expression signatures in psoriasis and to examine their potential influence on psoriasis pathogenesis. Methods. A miRNome PCR array was used to analyse the plasma of psoriasis patients and healthy donors. We performed miRNA pathway enrichment and target gene network analyses on psoriasis plasma samples. Results. We found several specific plasma miRNA signatures relevant to psoriasis. The miRNAs targeted pathways associated with psoriasis, such as the VEGF, MAPK, and WNT signaling pathways. Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. Conclusions. This study analysed the expression of plasma miRNAs and their target pathways, elucidating the pathogenesis of psoriasis; these results may be used to design novel therapeutic strategies and to identify diagnostic biomarkers for psoriasis.

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Section: Discussionmentioning

confidence: 99%

“…The JAK/STAT signaling pathway is relevant to autoimmune diseases, which indicates that psoriasis is an autoimmune disease [44]. In addition, JAK/STAT signaling pathway inhibition is used for treating psoriasis [45].…”

Section: Network Analysis Of Deregulated Plasma Mirnas Andmentioning

confidence: 99%

Plasma MicroRNA Expression Profiles in Psoriasis

Xiao

Liu

Wang

et al. 2020

Journal of Immunology Research

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“…In addition, GO analysis has shown that the blue module is predominantly involved in chemokine-mediated and complement receptor-mediated signaling and chemokine activity. Previous researches has confirmed that the plasma, lysosomal, and lytic vacuole membranes may be potential targets for treating sarcomas [55,[57][58][59][60].…”

Section: Discussionmentioning

confidence: 95%

“…[54]. The JAK-STAT signaling pathway transfer signals from cell membrane receptors to the nucleus in sarcoma tumors [55]. It modulate the activity of immune system, especially the fate of helper T cells [56].…”

Section: Discussionmentioning

confidence: 99%

Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma

Zhu

Hou²

2020

Preprint

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Background Sarcomas, cancers originating from mesenchymal cells, are comprehensive tumors with poor prognoses, yet their tumorigenic mechanisms are largely unknown. In this study, we aimed to characterize infiltrating immune cells and genes associated with the immunologic response to sarcomas. Method The “CIBERSORT” algorithm was used to calculate the amount of L22 immune cell infiltration in sarcomas. Then, the “ESTIMATE” algorithm was used to assess the “Estimate,” “Immune,” and “Stromal” scores. Weighted gene co-expression network analysis (WGCNA) was utilized to identify the significant module related to the immune therapeutic target. Gene ontology (GO) enrichment and Kyoto Encyclopedia of Gens and Genomes (KEGG) analysis were applied using the “clusterProfiler” package in R for annotation and visualization. Results Macrophages were the most common immune cells infiltrating sarcomas. The number of CD8 T cells was negatively associated with that of M0 and M2 macrophages, and positively associated with M macrophages in sarcomas samples. The clinical parameters (disease type, gender) significantly increased with higher Estimate, Immune, and Stromal scores, and with a better prognosis. The blue module was significantly associated with CD8 T cells. Functional enrichment analysis showed that the blue module was mainly involved in chemokine signaling and the PI3K-Akt signaling pathway. CD48, P2RY10 and RASAL3 were identified and validated at the protein level. Conclusion Based on the immune cell infiltration and immune microenvironment, three key genes were identified, which suggest novel molecular mechanisms of sarcoma metastasis.

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“…В серии открытых исследований установлена эффективность ТОФА при гнездной алопеции, в том числе у пациентов с сопутствующим псориазом [58]. К другим дерматологическим заболеваниям, при которых изучается возможность использования ингибиторов JAK, относятся витилиго, ладонно-подошвенный пустулез, идиопатическая многоформная эритема, кожная красная волчанка, ДМ [58,63,64], генерализованная морфея с эозинофильным фасциитом [65], кожный саркоидоз [66] и др.…”

Section: таблицаunclassified

Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects

Насонов

Лила

2019

Naučno-praktičeskaâ revmatologiâ

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Despite the great success in the diagnosis and treatment of immuno-inflammatory rheumatic diseases (IIRD), which led to a significant improvement in the prognosis in many patients, the fundamental medical problems of this pathology – the restoration of quality of life and reduction of mortality to the population level – are far from solution. This served as a powerful impetus to the study of new approaches to pharmacotherapy of IIRD, one of which is associated with the use of low-molecular synthetic drugs that inhibit intracellular "signal" molecules-Janus kinase (JAK), the socalled Jakinibs. The current achievements and trends concerning the use of JAK inhibitors in the treatment of IIRD are considered.

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JAK-STAT signaling pathway inhibition: a role for treatment of various dermatologic diseases

Cited by 16 publications

References 0 publications

Plasma MicroRNA Expression Profiles in Psoriasis

Plasma MicroRNA Expression Profiles in Psoriasis

Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma

Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects

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