JAK-STAT signaling in stem cells and their niches in<i>Drosophila</i>

Bausek, Nina

doi:10.4161/jkst.25686

Cited by 29 publications

(39 citation statements)

References 95 publications

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“…Activation of TOR signaling pathways through Rheb overexpression in EBs lead to higher dilp2, dilp3, dilp6 transcript levels in fly heads. Previous studies have shown that insulin-producing cells sense nutritional signals for DILP production in Upd2 and 3, activate the JAK/STAT pathway activity in ISCs [55]. We found higher Upd2 and Upd3 transcript levels when Rheb is overexpressed in Drosophila EBs, indicating that the JAK/STAT pathway is activated.…”

Section: Discussionsupporting

confidence: 52%

Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of Drosophila gut

et al. 2017

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Diverse physiological pathways have been shown to regulate longevity, stress resistance, fecundity and feeding rates, and metabolism in Drosophila. Here we tesed physiological traits in flies with Rheb and MycRheb overexpressed in gut progenitor cells, known as enteroblasts (EBs). We found that activation of TOR signaling by overexpression of Rheb in EBs decreases survival and stress resistance. Additionall, we showed that Myc co-expression in EBs reduces fly fecundity and feeding rate. Rheb overexpression enhanced the level of whole body glucose. Higher relative expression of the metabolic genes dilps, akh, tobi and pepck was, however, observed. The role of TOR/Myc in the regulation of genes involved in lipid metabolism and protein synthesis was established. We showed a significant role of TOR/ Myc in EBs in the regulation of the JAK/STAT, EGFR and insulin signaling pathways in Drosophila gut. These results highlight the importance of the balance between all different types of cells and confirm previous studies demonstrating that promotion of homeostasis in the intestine of Drosophila may function as a mechanism for the extension of organismal lifespan. Overall, the results demonstrate a role of TOR signaling and its downstream target Myc in EB cells in the regulation of Drosophila physiological processes.

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Section: Discussionsupporting

confidence: 52%

Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of Drosophila gut

et al. 2017

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“…Cancer cells also show frequent dysregulation of the JAK/STAT. Studies in Drosophila first implicated JAK-STAT signaling in the control of stem cell maintenance in the male germline stem cell microenvironment [130][131]. Tightly controlled JAK-STAT signaling is required for stem cell maintenance and self-renewal.…”

Section: Introductionmentioning

confidence: 99%

Stemness-related markers in cancer

2017

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Cancer stem cells (CSCs), with their self-renewal ability and multilineage differentiation potential, are a critical subpopulation of tumor cells that can drive tumor initiation, growth, and resistance to therapy. Like embryonic and adult stem cells, CSCs express markers that are not expressed in normal somatic cells and are thus thought to contribute towards a ‘stemness’ phenotype. This review summarizes the current knowledge of stemness-related markers in human cancers, with a particular focus on important transcription factors, protein surface markers and signaling pathways.

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“…Signaling ligands for this pathway Upd2 and 3 (Unpaireds) both contribute to ISC mitosis, and both of them trigger synthesis of the antimicrobial peptide drosomycin-3. Upds are sufficient to activate JAK/STAT pathway activity in ISCs [4].…”

Section: Jak/statmentioning

confidence: 99%

“…It is suggested, that stresses or infections upregulate JAK/STAT signaling. In these conditions, the signals back from EC and EB to ISC and promote ISC proliferation [4].…”

Section: Jak/statmentioning

confidence: 99%

Regulation of Drosophila Intestinal Stem Cell Maintenance and Proliferation

Strilbytska

2015

jpnu

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Abstract. To maintain gut homeostasis intestinal stem cells (ISCs) constantly replace damaged ones. This process is conservative from Drosophila to human. Proliferation and differentiation of ISCs in adult Drosophila midgut are regulated by growth factors which are secreted in the surrounding cells collectively forming ISCs niche. Here I discuss an interaction between ISCs with its niche through conservative signaling pathways. Several evidences on significance of cooperation between multiple signaling pathways including Notch, Wingless, JAK/STAT, EGFR, Hippo, and insulin signaling for regulation of stem cell maintenance and activity are provided. Further investigation in this area will allow us to understand how proper regulation of ISCs maintenance and differentiation can assist to ensure intestinal integrity.

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JAK-STAT signaling in stem cells and their niches inDrosophila

Cited by 29 publications

References 95 publications

Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of Drosophila gut

Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of Drosophila gut

Stemness-related markers in cancer

Regulation of Drosophila Intestinal Stem Cell Maintenance and Proliferation

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