“…1 T-LGL leukemia have also been seen in various T-cell neoplasms, including gd hepatosplenic T-cell lymphoma, 13 T-cell acute lymphoblastic leukemia, 14,15 T-cell prolymphocytic leukemia, 16 type II enteropathy-associated T-cell lymphoma, 17 and extranodal NK/T-cell lymphoma, 18 suggesting that these are shared with other T-cell malignancies. The analyses of STAT5 target genes with chromatin immunoprecipitation sequencing have shown that STAT5B is a key factor in T-cell development, binding to molecules such as DOCK8, SNX9, FOXP3, and IL2RA.…”