Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, Stuttgart, 29. September-3. Oktober 2017: Abstracts

Murawski, Niels; Amam, Josif; Altmann, Bettina; Ziepert, Marita; Haenel, Mathias; Viardot, Andreas; Neubauer, Andreas; Held, G.; Truemper, Lorenz; Schmidt, C.; Kanz, Lothar; Hallek, M.; Schmitz, Norbert; Heintges, Tobias; Koelbel, C.; Poeschel, Viola; Pfreundschuh, Michael

doi:10.1159/000479566

Cited by 19 publications

(27 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Twelve full text articles were included for final analysis: three RCT's [16][17][18] five single arm prospective trials [19][20][21][22][23], three case reports [24][25][26] and one case series [27]. In the three RCT's, one study involved participants being randomised to an exercise intervention or control group [16], and two studies involved participants being randomised to a supervised exercise group, an unsupervised exercise group, or control group [17,18].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Within the three RCT's included [16][17][18], the mean PE-Dro score was 6.3 (0.6 SD). When all included studies were evaluated using the EPHPP tool, one of the twelve studies received a strong global rating [16], two a moderate rating [17,18] and nine were rated as weak [19][20][21][22][23][24][25][26][27]. Limitations in weak study methodologies included study design, lack of blinding and lack of reporting of confounders.…”

Section: Risk Of Biasmentioning

confidence: 99%

“…One study implemented exercise in an individual with inoperable disease [26]. One study included an exercise intervention delivered during palliative chemotherapy, neo-adjuvant chemotherapy and following surgery during adjuvant chemotherapy [25]. McLaughlin et al, [26] in their case report had their participant complete 40 min of aerobic exercise on a cycle ergometer at 60% heart rate maximum (HR max ) during chemotherapy infusions.…”

Section: Study Settingmentioning

confidence: 99%

“…Of these, 157 (52%) were male, and 143 (48%) were female. The mean age of participants included in this review ranged from 46 [25] to 74 years [27]. The study by Banzer et al, [21] involved a heterogenous group of cancer patients (n = 101), which included three pancreatic cancer patients.…”

Section: Participant Demographicsmentioning

confidence: 99%

“…Of the twelve included studies, two studies focused on aerobic exercise only [16,21], four studies focused on resistance training only [17,18,22,23], and six studies included a combination of aerobic and resistance exercise [19,20,[24][25][26][27]. Six studies used unsupervised home-based exercise [16,[19][20][21][22][23], four studies used supervised exercise [24][25][26][27] with locations reported in two studies which included an exercise clinic [24] and hospital [26]. Two studies used supervised (university exercise facility) and home-based, unsupervised exercise [17,18].…”

Section: Exercise Prescription In Pancreatic Cancermentioning

confidence: 99%

See 4 more Smart Citations

Exercise efficacy and prescription during treatment for pancreatic ductal adenocarcinoma: a systematic review

et al. 2021

View full text Add to dashboard Cite

Background Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. As such, optimizing physical function through exercise during treatment remains imperative to optimize quality of life either before surgery or during rehabilitation. However, current exercise efficacy and prescription in pancreatic cancer is unknown. Therefore, this study aims to summarise the published literature on exercise studies conducted in patients with pancreatic cancer undergoing treatment with a focus on determining the current prescription and progression patterns being used in this population. Methods A systematic review of four databases identified studies evaluating the effects of exercise on aerobic fitness, muscle strength, physical function, body composition, fatigue and quality of life in participants with pancreatic cancer undergoing treatment, published up to 24 July 2020. Two reviewers independently reviewed and appraised the methodological quality of each study. Results Twelve studies with a total of 300 participants were included. Heterogeneity of the literature prevented meta-analysis. Exercise was associated with improvements in outcomes; however, study quality was variable with the majority of studies receiving a weak rating. Conclusions High quality evidence regarding the efficacy and prescription of exercise in pancreatic cancer is lacking. Well-designed trials, which have received feedback and input from key stakeholders prior to implementation, are required to examine the impact of exercise in pancreatic cancer on key cancer related health outcomes.

show abstract