Jackfruit (<i>Artocarpus heterophyllus</i> Lam.) oligopeptides regulate immune responses <i>via</i> Th cell stimulation, cytokine secretion and antibody production

Hao, Yuntao; Liu, Xin-Ran; Zhu, Na; Mao, Ruixue; Li, Rui; Wu, Lan; Kang, Jia-Wei; Hu, Jiani; Li, Yong

doi:10.1039/d0fo01294g

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Particularly, compared with the control group, LPK was shown to have the best-inhibited effect on the activity of LDH among the five oligopeptides ( P > 0.05). Similarly, jackfruit-derived oligopeptides were rigorously investigated to downregulate the activity of LDH in Th cells . Furthermore, NO is also synthesized in the stress response with ROS generated.…”

Section: Resultsmentioning

confidence: 99%

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Assessment of Novel Oligopeptides from Rapeseed Napin (Brassica napus) in Protecting HepG2 Cells from Insulin Resistance and Oxidative Stress

Yao

et al. 2022

J. Agric. Food Chem.

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Oligopeptides (Thr–His–Leu–Pro–Lys (THLPK), His–Pro–Leu–Lys (HPLK), Leu–Pro–Lys (LPK), His–Leu–Lys (HLK), and Leu–His–Lys (LHK)) are newly identified from rapeseed napin (Brassica napus) protein-derived hydrolysates with the capability of upregulating glucose transporter-4 (GLUT4) expression and translocation. However, whether each of them enhances GLUT4 expression and translocation and their specific mechanisms remain unclear. Here, we assess the effects of the oligopeptides against insulin resistance (IR) and oxidative stress in hepatocytes and screen out the most antidiabetic one. Specifically, compared with other oligopeptides, LPK not only remarkably elevated glucose consumption to 8.45 mmol/L protein; superoxide dismutase (SOD) activity to 319 U/mg protein; GLUT4 expression and translocation; and phosphorylated level of insulin receptor substrate-1 (IRS-1), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt) (P < 0.05) but also remarkably attenuated the reactive oxygen species (ROS) level to 2255, lactate dehydrogenase (LDH) activity to 20.5 U/mg protein, malondialdehyde (MDA) content to 241 nmol/mg protein, and NO content to 1302 μmol/mL protein (P < 0.05). These findings demonstrated that antidiabetic oligopeptide LPK possessed the most potential to protect HepG2 cells from IR and oxidative stress via activating IRS-1/PI3K/Akt/GLUT4 and regulating common oxidative markers in vitro.

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Section: Resultsmentioning

confidence: 99%

“…Similarly, jackfruit-derived oligopeptides were rigorously investigated to downregulate the activity of LDH in Th cells. 67 Furthermore, NO is also synthesized in the stress response with ROS generated. In other words, the ROS level is decreased by downregulating the content of NO.…”

Section: Oligopeptides Restore the Abnormal Expression And Translocat...mentioning

confidence: 99%

Assessment of Novel Oligopeptides from Rapeseed Napin (Brassica napus) in Protecting HepG2 Cells from Insulin Resistance and Oxidative Stress

Yao

et al. 2022

J. Agric. Food Chem.

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Jackfruit and its beneficial effects in boosting digestion and immune-enhancing properties

Sowmyashree¹,

Kumar

Sannaningaiah

2022

Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health

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Jackfruit ( Artocarpus heterophyllus Lam.) in health and disease: a critical review

Gupta

Marquess

Pandey

et al. 2022

Critical Reviews in Food Science and Nutrition

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Jackfruit (Artocarpus heterophyllus Lam.) oligopeptides regulate immune responses via Th cell stimulation, cytokine secretion and antibody production

Abstract: This study aimed to observe the immunomodulatory effects of oligopeptides derived from Jackfruit (Artocarpus heterophyllus Lam.) (JOPs). 200 female BALB/c mice in five groups were respectively given deionized water (control),...

Cited by 4 publications

References 29 publications

Assessment of Novel Oligopeptides from Rapeseed Napin (Brassica napus) in Protecting HepG2 Cells from Insulin Resistance and Oxidative Stress

Assessment of Novel Oligopeptides from Rapeseed Napin (Brassica napus) in Protecting HepG2 Cells from Insulin Resistance and Oxidative Stress

Jackfruit and its beneficial effects in boosting digestion and immune-enhancing properties

Jackfruit ( Artocarpus heterophyllus Lam.) in health and disease: a critical review

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