Jaceosidin inhibits the progression and metastasis of NSCLC by regulating miR-34c-3p/Integrin α2β1 axis

Guo, Qiaoru; Zhou, Wenmin; Zhang, Guobin; Deng, Zhuo-fen; Chen, X.; Sun, Fangyun; Lei, Xueping; Yan, Yanyan; Zhang, Jianye

doi:10.1016/j.heliyon.2023.e16158

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Studies have revealed that Jaceosidin is able to induce apoptosis in gastric cancer cells by regulating ROSmediated signaling pathways 50 and is able to inhibit the progression and metastasis of NSCLC. 51 Luteolin performs various anticancer effects mainly by inhibiting proliferation and invasion, stimulating apoptosis, intercepting the cell cycle, regulating autophagy and immunity, inhibiting inflammatory responses, inducing iron death and pyroptosis, and epigenetic modifications. 52 Lanatoside C can target the ZDHHC21/ FASN axis for treating diffuse large B-cell lymphoma 53 and can inhibit the proliferation of cholangiocarcinoma and promote apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…There are various previous studies on these active ingredients. Studies have revealed that Jaceosidin is able to induce apoptosis in gastric cancer cells by regulating ROS-mediated signaling pathways and is able to inhibit the progression and metastasis of NSCLC . Luteolin performs various anticancer effects mainly by inhibiting proliferation and invasion, stimulating apoptosis, intercepting the cell cycle, regulating autophagy and immunity, inhibiting inflammatory responses, inducing iron death and pyroptosis, and epigenetic modifications .…”

Section: Discussionmentioning

confidence: 99%

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Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Zhu,

Liang,

Guo

et al. 2024

ACS Omega

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Anaplastic thyroid cancer (ATC) is one of the most lethal malignant tumors for which there is no effective treatment. There are an increasing number of studies on herbal medicine for treating malignant tumors, and the classic botanical medicine Digitalis and its active ingredients for treating heart failure and arrhythmias have been revealed to have significant antitumor efficacy against a wide range of malignant tumors. However, the main components of Digitalis and the molecular mechanisms of its anti-ATC effects have not been extensively studied. Here, we screened the main components and core targets of Digitalis and verified the relationship between the active components and targets through network pharmacology, molecular docking, and experimental validation. These experiments showed that the active ingredients of Digitalis inhibit ATC cell activity and lead to ATC cell death through the apoptotic pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Zhu,

Liang,

Guo

et al. 2024

ACS Omega

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Bioinformatics analysis and validation of CSRNP1 as a key prognostic gene in non-small cell lung cancer

Xu,

Zhou,

Luo

et al. 2024

Heliyon

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Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

Liu,

Luo,

2024

Life

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The global prevalence of obesity is a pressing health issue, increasing the medical burden and posing significant health risks to humans. The side effects and complications associated with conventional medication and surgery have spurred the search for anti-obesity drugs from plant resources. Previous studies have suggested that Artemisiae argyi Folium (Aiye) water extracts could inhibit pancreatic lipase activities, control body weight increase, and improve the plasma lipids profile. However, the exact components and mechanisms were not precisely understood. Therefore, this research aims to identify the chemical profile of Aiye and provide a comprehensive prediction of its anti-obesity mechanisms. The water extract of Aiye was subjected to LC-MS analysis, which identified 30 phenolics. The anti-obesity mechanisms of these phenolics were then predicted, employing network pharmacology and molecular docking. Among the 30 phenolics, 21 passed the drug-likeness screening and exhibited 486 anti-obesity targets. The enrichment analysis revealed that these phenolics may combat obesity through PI3K-Akt signaling and MAPK, prolactin, and cAMP signaling pathways. Eight phenolics and seven central targets were selected for molecular docking, and 45 out of 56 docking had a binding affinity of less than −5 kcal/mol. This research has indicated the potential therapy targets and signaling pathways of Aiye in combating obesity.

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Jaceosidin inhibits the progression and metastasis of NSCLC by regulating miR-34c-3p/Integrin α2β1 axis

Cited by 3 publications

References 40 publications

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

Bioinformatics analysis and validation of CSRNP1 as a key prognostic gene in non-small cell lung cancer

Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

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