2000
DOI: 10.1074/jbc.275.12.8540
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JAB1 Interacts with Both the Progesterone Receptor and SRC-1

Abstract: JAB1 (Jun activation domain-binding protein-1) has previously been described as a coactivator of AP1 transcription factor. We show here, by yeast and mammalian two-hybrid analyses and by pull-down experiments, that JAB1 also interacts with both the progesterone receptor (PR) and the steroid receptor coactivator 1 (SRC-1) and that it stabilizes PR-SRC-1 complexes. We also show that JAB1 potentiates the activity of a variety of transcription factors known to associate with SRC-1 (nuclear receptors, activator pro… Show more

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Cited by 99 publications
(85 citation statements)
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“…Jab1 in the nucleus functions as transcription coactivator and may interact and modulate the activity of steroid receptors as demonstrated previously. 33,34 Our results indeed demonstrated a marginal correlation between Jab1 and estrogen receptor or progesterone receptor ( Table 2). The functional interaction between steroid receptors and Jab1 received much attention recently.…”
Section: Discussionsupporting
confidence: 52%
“…Jab1 in the nucleus functions as transcription coactivator and may interact and modulate the activity of steroid receptors as demonstrated previously. 33,34 Our results indeed demonstrated a marginal correlation between Jab1 and estrogen receptor or progesterone receptor ( Table 2). The functional interaction between steroid receptors and Jab1 received much attention recently.…”
Section: Discussionsupporting
confidence: 52%
“…Intracellular MIF interacted with the signalosome component JAB1/CSN5 and was shown to regulate both the activity of tumor suppressor p53 and the angiogenesis induced by hypoxia [17,18]. Interestingly, JAB1/CSN5 was further shown to interact with PR and SRC-1 and potentiated the activity of a variety of transcription factors known to associate with SRC-1, such as AP-1 and NF-κB [19][20][21]. In addition, JAB1 expression was required for the rapid and transient activation of ERK by MIF, and the ability of JAB1/CSN5 to activate AP-1 is modulated by interaction with MIF [22,23].…”
Section: Introductionmentioning
confidence: 99%
“…Tagged Smad3, Smad4, and Smad7 expression vectors (gifts from Dr A Roberts, NIH, Bethesda, MD, USA) were previously described (de Caestecker et al, 1998). Plasmids encoding the wild-type human SRC-1 (pSG5-HA-SRC-1) and deletion mutant (pSG5-HA-Dp300SRC-1) (kind gift from E Milgrom, INSERM U135, Le Kremlin-Bicetre, France), p300 (kind gift from Dr T Shioda, Boston, MA, USA), E1A and deletion mutant mE1A (gift from Dr A Roberts, NIH, Bethesda, MD, USA) have been previously described (respectively by Chauchereau et al, 2000;de Caestecker et al, 2000).…”
Section: Plasmid Constructsmentioning
confidence: 99%
“…G5E1b-Lux containing five Gal4 binding sites driving the expression of luciferase and Gal4BD-Smad3 fusion protein expression vector, containing the full-length Smad3 cDNA have been described previously (Atfi et al, 1997). Additional expression vectors used in this study were: Gal4BD-p300 (a kind gift from Dr A Giordano, Thomas Jefferson University, Philadelphia, PA, USA) (Yuan et al, 1996) and VP16AD-SRC-1 (kind gift from E Milgrom, INSERM U135, Kremlin-Bicetre, France) (Chauchereau et al, 2000).…”
Section: Plasmid Constructsmentioning
confidence: 99%
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