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Abstract

Objective: The aim of this study is to investigate whether exposure to subclinical dose of sodium nitrite for long term can trigger histopathological changes which are able to detect by using hematoxylin and eosin stain. Sodium nitrite has various properties that make it widely used in industrial and pharmaceutical fields. Method: Three groups of mice were used in this study; the first group was administered sodium nitrite in the drinking water for six months and the second group for eighteen months meantime the third one was used as a control. Then histopathological examination was done. Results: The results revealed that there were histopathological changes in the various tissues and organs which appeared in both exposed groups. Most changes mainly reversible except few areas in the liver and no obvious carcinogenic changes were detected by hematoxylin and eosin stain. Conclusion: The ultimate conclusion obtained from this study indicated that prolonged exposure to subclinical dose of sodium nitrite induced reversible histopathological changes in different tissues and organs except few and small areas in the liver.