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Bullen,

doi:10.1016/s1076-0512(98)00080-6

Cited by 14 publications

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“…The current primary treatment of AS involves complete excision of the tumor and adjuvant radiotherapy; however, the prognosis of AS remains obscure. We assume the mapping biopsy helps in determining surgical margin in advance, and the effectiveness of such procedure has been affirmed through previous studies in AS and extramammary Paget's disease [ 25 , 26 ]. This method facilitates the detection of occult satellite lesions, and it provides indications of the more extensive resection.…”

Section: Discussionmentioning

confidence: 83%

Surgical Treatment and Prognosis of Angiosarcoma of the Scalp: A Retrospective Analysis of 14 Patients in a Single Institution

Choi

Ahn

Chang

et al. 2015

BioMed Research International

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Objective. We describe specific surgical methods for angiosarcoma regarding extent of resection and reconstructive options and assess their effect on patients' prognosis. Patients and Methods. We retrospectively examined 14 patients undergoing treatment for angiosarcoma of the scalp at our institute between January 2000 and June 2015. Surgical treatment comprised wide excision of the tumor and reconstruction using a free flap with skin graft. Kaplan-Meier survival analysis was used to assess the survival parameters. Univariate and multivariate analyses were performed to evaluate the association between risk factors and outcome parameters. Results. Mean patient age at diagnosis was 69 years, and the mean follow-up period was 17 months. The overall 5- and 2-year survival rates were 15% and 75%, respectively, whereas the 5- and 2-year disease-free survival rates were 7.7% and 38.7%, respectively. The mean survival duration was 32 months. Metastatic tumor dissemination to the lung or brain was closely associated with the major cause of death. Only a deep excision margin was significantly related to the recurrence rate. Conclusions. Cases of angiosarcoma had a poor prognosis despite the aggressive treatments. Sufficient resection margins are essential for controlling local recurrence. The effect of multidisciplinary approaches needs to be explored.

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Section: Discussionmentioning

confidence: 83%

Surgical Treatment and Prognosis of Angiosarcoma of the Scalp: A Retrospective Analysis of 14 Patients in a Single Institution

Choi

Ahn

Chang

et al. 2015

BioMed Research International

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“…The utility of Mohs micrographic surgery in the treatment of angiosarcoma has not been examined prospectively, and retrospective studies limited to single cases and small series show variable success. 27–29 There is considerable debate regarding the indications for Mohs surgery in soft tissue tumors and particularly angiosarcoma, given the propensity for multifocal growth and notorious difficulty achieving negative margins. 13 While our experience is also limited by small numbers, we found no difference in survival between patients who underwent Mohs surgery compared to wide local excision for amenable lesions.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma Outcomes and Prognostic Factors

Buehler¹,

Rice

Moody

et al. 2014

American Journal of Clinical Oncology

150

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Objective Angiosarcoma is an aggressive malignancy with endothelial differentiation and notoriously poor prognosis despite aggressive therapy. Limited data are available to guide management decisions. To address this limitation, we present a large retrospective analysis of angiosarcoma patients treated at a single institution over a 25-year period. Methods To identify factors that impact angiosarcoma outcomes, we reviewed demographic, tumor and treatment characteristics of angiosarcoma patients evaluated at the University of Wisconsin Hospital between 1987 and 2012. Results The cohort included 81 patients diagnosed at age 19–90 yo (median 67). Fifty-five (68%) patients presented with localized disease while 26 (32%) presented with metastases. The primary sites were visceral/deep soft tissue (42%), head and neck/cutaneous (37%), breast (16%) and limbs in the setting of Stewart-Treves (5%). The 5-year overall survival (OS) was 40% with a median of 16 months. By univariate analysis, significant adverse predictors of survival included metastases at presentation, visceral/deep soft tissue tumor location, tumor size > 5 cm, tumor necrosis and the absence of surgical excision. A trend toward prolonged survival was observed with radiation therapy and for chemotherapy in patients with metastases. Age, sex, and prior radiation showed no correlation with survival. Conclusions Our large single institution series confirms the poor prognosis of angiosarcoma, supports a central role for surgical excision in management and highlights the need for novel therapies particularly in patients who present with metastatic disease.

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Maligne Tumoren der Haut

Operative Dermatologie

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Abstract: Local control of AS of the scalp may be achieved by assessment of the tumor margin by peripheral biopsies or Mohs technique followed by electron beam and radiation.

Cited by 14 publications

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Surgical Treatment and Prognosis of Angiosarcoma of the Scalp: A Retrospective Analysis of 14 Patients in a Single Institution

Surgical Treatment and Prognosis of Angiosarcoma of the Scalp: A Retrospective Analysis of 14 Patients in a Single Institution

Angiosarcoma Outcomes and Prognostic Factors

Maligne Tumoren der Haut

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