J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

Li, Kang; Duan, Xingchen; Jiang, Zhiyong; Ding, Dan; Chen, Yuncong; Zhang, Guo‐Qiang; Liu, Zhipeng

doi:10.1038/s41467-021-22686-z

Cited by 187 publications

(126 citation statements)

References 62 publications

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“…That is to say that although the intermolecular interactions were not eliminated by tert -butyl units on the periphery, it positively led to intermolecular aggregation-enhanced emission, identified as J-aggregation. 44–47 Meanwhile, the PL quantum efficiency (∅ PL ) of pure films also verified that the introduction of tert -butyl group helped increase the luminescence efficiency. The ∅ PL of 5ph-bodipy was 2.1%, while the ∅ PL of 5tbuph-bodipy was 3.6%.…”

Section: Resultsmentioning

confidence: 82%

A periphery hindered strategy with a dopant and sensitizer for solution-processed red TSF-OLEDs with high color purity

et al. 2022

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Section: Resultsmentioning

confidence: 82%

A periphery hindered strategy with a dopant and sensitizer for solution-processed red TSF-OLEDs with high color purity

et al. 2022

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Section: Photophysical Property Changes Of Conventional Fluorophore A...mentioning

confidence: 99%

Recent trends in molecular aggregates: An exploration of biomedicine

et al. 2022

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Molecular aggregates are receiving tremendous attention, demonstrating immense potential for biomedical applications in vitro and in vivo. For instance, the molecular aggregates of conventional fluorophores influence the electronic excitation states of the aggregates, causing characteristic photophysical property changes. A fundamental understanding of this classical relationship between molecular aggregate structures and photophysics has allowed for innovative biological applications. The chemical characteristics of drug molecules generally trigger the formation of colloidal aggregates, and this is considered detrimental to the drug discovery process. Furthermore, nano-sized supramolecular aggregates have been used in biomedical imaging and therapy owing to their optimal properties for in vivo utility, including enhanced cell permeability, passive tumor targeting, and convenient surface engineering. Herein, we provide an overview of the recent trends in molecular aggregates for biomedical applications. The changes in photophysical properties of conventional fluorophores and their biological applications are discussed, followed by the effects of conventional drug molecule-aggregates on drug discovery and therapeutics development. Recent trends in the investigation of biologically important analytes with aggregation-induced emission are discussed for conventional and unconventional fluorophores. Lastly, we discuss nano-sized supramolecular aggregates used in imaging and therapeutic purposes, with a focus on in vivo utilization.

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“…Reproduced with permission. [73] Copyright 2021, Springer Nature. www.advopticalmat.de with the NIR-I region, the NIR-II region significantly reduces the scattering and autofluorescence of biological tissues, thus greatly improving the imaging resolution and depth.…”

Section: D-a Type Dye Based On Benzobisthiadiazoles (Bbtd)mentioning

confidence: 99%

The Design and Bioimaging Applications of NIR Fluorescent Organic Dyes with High Brightness

Shi

Zhu

et al. 2022

Advanced Optical Materials

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Due to the merits of decreased photon attenuation, autofluorescence, and scattering, the near‐infrared (NIR, 700–1700 nm) region is an important window in the field of biomedicine, such as in vivo fluorescence imaging, in which both the optical detection depth and the resolution/contrast have been significantly improved. In particular, for second NIR (NIR‐II, 1000–1700 nm) dyes, biological tissues have almost no background interference. Typical fluorophores have excellent spectral performance and rich functional modification sites and can be optimized into NIR dyes for bioimaging. However, as the absorption/emission wavelength of fluorophores redshift to NIR, it is challenging to keep fluorophores with satisfying brightness. Therefore, for the purpose of increasing the absorption/emission wavelength of dye while promoting its brightness, it is necessary to study the structure–property relationship of the dyes. This review introduces the influences of fluorophores’ structure on their photophysical properties, summarizes the strategies for maintaining high fluorescence brightness along with redshifted absorption/emission wavelengths, and the latest advances of highly fluorescent brightness dyes. Finally, the opportunities and challenges in this emerging field are also provided. The authors aim to provide insightful design guidelines and clear overview of highly bright NIR fluorescent dyes, which might trigger new ideas and applications.

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J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

Cited by 187 publications

References 62 publications

A periphery hindered strategy with a dopant and sensitizer for solution-processed red TSF-OLEDs with high color purity

A periphery hindered strategy with a dopant and sensitizer for solution-processed red TSF-OLEDs with high color purity

Recent trends in molecular aggregates: An exploration of biomedicine

The Design and Bioimaging Applications of NIR Fluorescent Organic Dyes with High Brightness

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