Ixodid tick salivary gland extracts suppress human transforming growth factor-β1 triggered signalling pathways in cervical carcinoma cells

Holíková, Viera; Štibrániová, Iveta; Bartíková, Pavlína; Slovák, Mirko; Kazimírová, Mária

doi:10.2478/s11756-018-0129-z

Cited by 1 publication

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“…Tick saliva is a mixture of proteins, peptides and non-peptide molecules that interfere with various components of hemostasis, wound healing, and both arms of the immune system of the vertebrate hosts, including enzymes, cytokines, complement, antibodies, cell signaling components, immune cells (Francischetti et al, 2009; Mans, 2016; Nuttall, 2018; Wikel, 2018). In addition, cytotoxic and cytolitic activities acting against different cell types, impairment of cancer cells migration and signaling pathways, as well as anti-angiogenic properties have been demonstrated for saliva of different hard tick species (Kazimirova et al, 2006; Poole et al, 2013; Holíková et al, 2018; Sousa et al, 2018; de Sá Jr. et al, 2019; Gradowski do Nascimento et al, 2019), showing that tick saliva is an important source for designing new anticancer drugs (Kazimírová, 2011; Sousa et al, 2015; Chudzinski-Tavassi et al, 2016). Proteinaceous components of the tick saliva are grouped into families like lipocalins, proteins with Kunitz type domain, metalloproteases, serpins, cystatins, basic-tail secreted proteins, small peptide inhibitors, some protein families unique to ticks, and proteins and peptides of unknown structure and function (Ribeiro et al, 2006; Francischetti et al, 2009; Chmelar et al, 2012).…”

Section: Ticks and Pharmacological Properties Of Their Salivamentioning

confidence: 99%

Deciphering Biological Processes at the Tick-Host Interface Opens New Strategies for Treatment of Human Diseases

et al. 2019

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Ticks are obligatory blood-feeding ectoparasites, causing blood loss and skin damage in their hosts. In addition, ticks also transmit a number of various pathogenic microorganisms that cause serious diseases in humans and animals. Ticks evolved a wide array of salivary bioactive compounds that, upon injection into the host skin, inhibit or modulate host reactions such as hemostasis, inflammation and wound healing. Modulation of the tick attachment site in the host skin involves mainly molecules which affect physiological processes orchestrated by cytokines, chemokines and growth factors. Suppressing host defense reactions is crucial for tick survival and reproduction. Furthermore, pharmacologically active compounds in tick saliva have a promising therapeutic potential for treatment of some human diseases connected with disorders in hemostasis and immune system. These disorders are often associated to alterations in signaling pathways and dysregulation or overexpression of specific cytokines which, in turn, affect mechanisms of angiogenesis, cell motility and cytoskeletal regulation. Moreover, tick salivary molecules were found to exert cytotoxic and cytolytic effects on various tumor cells and have anti-angiogenic properties. Elucidation of the mode of action of tick bioactive molecules on the regulation of cell processes in their mammalian hosts could provide new tools for understanding the complex changes leading to immune disorders and cancer. Tick bioactive molecules may also be exploited as new pharmacological inhibitors of the signaling pathways of cytokines and thus help alleviate patient discomfort and increase patient survival. We review the current knowledge about tick salivary peptides and proteins that have been identified and functionally characterized in in vitro and/or in vivo models and their therapeutic perspective.

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