“…The 5-year survival rate of patients who have undergone curative resection remains disappointingly low, averaging 20 per cent in most series but varying from 10 to 35 per cent 6,12,13,19,21 . Prognostic factors include the degree of oesophageal wall penetration (which correlates with the risk of nodal involvement) 22 , the number of lymph nodes involved 23±25 and the site of the primary tumour; lower oesophageal tumours carry a worse prognosis than mid or upper oesophageal tumours 26,27 .…”
Section: Introductionmentioning
confidence: 94%
“…Despite improvements in operative surgery, intensive care medicine and supportive care, no signi®cant increase in overall survival has been achieved. Both distant metastases and locoregional recurrence occur equally commonly 13,21,25,28 . Extended lymphadenectomy may improve locoregional control but does not seem to affect overall survival 29 .…”
Preoperative CRT may improve survival. Emerging evidence suggests that CRT alone can achieve similar survival rates to surgery alone. New imaging modalities may help to select which patients require surgery. Larger randomized trials of preoperative CRT or chemotherapy are needed to define optimal regimens and produce higher pCR rates with acceptable toxicity.
“…The 5-year survival rate of patients who have undergone curative resection remains disappointingly low, averaging 20 per cent in most series but varying from 10 to 35 per cent 6,12,13,19,21 . Prognostic factors include the degree of oesophageal wall penetration (which correlates with the risk of nodal involvement) 22 , the number of lymph nodes involved 23±25 and the site of the primary tumour; lower oesophageal tumours carry a worse prognosis than mid or upper oesophageal tumours 26,27 .…”
Section: Introductionmentioning
confidence: 94%
“…Despite improvements in operative surgery, intensive care medicine and supportive care, no signi®cant increase in overall survival has been achieved. Both distant metastases and locoregional recurrence occur equally commonly 13,21,25,28 . Extended lymphadenectomy may improve locoregional control but does not seem to affect overall survival 29 .…”
Preoperative CRT may improve survival. Emerging evidence suggests that CRT alone can achieve similar survival rates to surgery alone. New imaging modalities may help to select which patients require surgery. Larger randomized trials of preoperative CRT or chemotherapy are needed to define optimal regimens and produce higher pCR rates with acceptable toxicity.
“…1 Although the best approach to esophagectomy remains controversial, the 2 most frequently performed operations are transthoracic (TT) and blunt transhiatal esophagectomy (THE). [2][3] The transthoracic approach allows the surgeon to perform a wide mediastinal lymphadenectomyandprovideadequatehemostasis that cannot be ensured by THE. However, THE avoids a thoracotomy and therefore reduces associated pulmonary complications.…”
Hypothesis: Minimally invasive esophagectomy can be performed as safely as conventional esophagectomy and has distinct perioperative outcome advantages.Design: A retrospective comparison of 3 methods of esophagectomy: minimally invasive, transthoracic, and blunt transhiatal.Setting: University medical center.
“…Numerous authors have reported mortality and complication rates. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] Recently, we identified two patients' status post-Ivor Lewis esophagectomy, each with a similar and unusual symptomatic complication -markedly redundant intrathoracic stomach. The description of this complication and its surgical repair is described.…”
We present two patients with low esophagogastric anastomosis, redundant intrathoracic stomach, and markedly symptomatic reflux and regurgitation after Ivor Lewis esophagectomy. The diagnosis, technique of surgical revision, and outcome is discussed.
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