IVF outcome in patients with orthotopically transplanted ovarian tissue

Dolmans, Marie-Madeleine; Donnez, Jacques; Camboni, Alessandra; Demylle, Dominique; Amorim, Christiani Andrade; Langendonckt, Anne Van; Pirard, Céline

doi:10.1093/humrep/dep289

Cited by 114 publications

(82 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, extensive investigations on the effects of cryoprotectants on both human and animal ovarian tissue have not revealed any potential side effects. However, studies in women who had frozen-thawed ovarian tissue transplanted have revealed that follicles developing in the transplanted ovarian tissue are more often without oocytes and that the in vitro fertilization (IVF) pregnancy rate is relatively low compared to standard IVF patients [5,6]. Additionally, the ovarian tissue is often transported close to zero degrees for up to 24 h, which of course is not the case of mature oocytes and embryos.…”

Section: Introductionmentioning

confidence: 99%

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

Jensen

Macklon²,

Fedder

et al. 2016

J Assist Reprod Genet

247

160

View full text Add to dashboard Cite

Purpose This study aims to make an account of the children born following transplantation of frozen-thawed ovarian tissue worldwide with specific focus on the perinatal outcome of the children. Furthermore, perinatal outcome of seven deliveries (nine children) from Denmark is reported. Methods PubMed was searched for papers of deliveries resulting from ovarian tissue cryopreservation (OTC). Seven women underwent OTC prior to chemotherapy. Four of these women still had low ovarian function and had tried to conceive. They therefore had tissue autotransplanted to augment their fertility. The other three women had developed premature ovarian insufficiency (POI) after the end of treatment.Results Worldwide, approximately 95 children have been born or will be born in the near future from OTC, including these 9 new children. Information on the perinatal outcome was found on 40 children. The mean gestational age was 39 weeks and the mean birth weight was 3168 g of the singleton pregnancies, which is within internationally recognized normal standards. Furthermore, half the singletons resulted from natural conception and all twins resulted from in vitro fertilization treatment. All seven Danish women became pregnant within 1-3 years after transplantation. They gave birth to nine healthy children. Conclusion The data is reassuring and further suggests that cryopreservation of ovarian tissue is becoming an established fertility preservation method. The seven Danish women reported in this study were all in their early thirties when OTC was performed. Most other reported cases were in the women's twenties. This suggests that the follicular pool in the thirties is large enough and sufficient to sustain fertility.Keywords Fertility preservation . Cryopreservation . Ovarian tissue transplantation . Deliveries IntroductionOvarian tissue cryopreservation (OTC) and transplantation is a relatively new procedure within the area of assisted reproduction technologies (ART). OTC differs from other ART procedures like freezing oocytes or embryos by cryopreserving intact tissue containing small non-growing follicles [1,2]. Although the cryoprotectant media used to freeze ovarian tissue resemble those media used for oocytes and embryos, there are often subtle differences [3,4]. Furthermore, extensive investigations on the effects of cryoprotectants on both human and animal ovarian tissue have not revealed any potential side effects. However, studies in women who had frozen-thawed ovarian tissue transplanted have The original version of this article was revised: There were errors in the Discussion section and the last paragraph should be removed.Capsule The data is reassuring and further suggests that cryopreservation of ovarian tissue is becoming an established fertility preservation method.

show abstract

Section: Introductionmentioning

confidence: 99%

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

Jensen

Macklon²,

Fedder

et al. 2016

J Assist Reprod Genet

247

160

View full text Add to dashboard Cite

show abstract

“…In addition, laparoscopy and general anesthesia are required, inducing a delay of 2-6 weeks in starting CT. Importantly, the efficacy of these treatments in patients > 40 years of age seems to be uncertain [83].…”

Section: Preserving Fertility In Breast Cancer Patientsmentioning

confidence: 99%

Chemotherapy-induced ovarian toxicity in patients affected by endocrine-responsive early breast cancer

Torino

Barnabei²,

Vecchis

et al. 2014

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

“…Few experimental studies have tested the human ovarian tissue from both HL or NHL and failed to show evidence of ovarian involvement by lymphoma cells [18,20,24,25]. To date, 15 auto-transplantations have been reported in HL patients and 6 in NHL without any disease recurrence, knowing that the follow-up after autotransplantation in one of the HL patients is now up to 8 years [19,[26][27][28][29][30][31][32][33][34]. Nevertheless, a recent case-report showed an ovarian involvement in the histologic examination of ovarian cortex pieces in a stage III HL [15].…”

Section: Discussionmentioning

confidence: 99%

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Gronier

Terriou

Robin

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

IVF outcome in patients with orthotopically transplanted ovarian tissue

Abstract: IVF in women with orthotopically grafted frozen-thawed ovarian tissue involves a higher risk of empty follicles, abnormal or immature oocytes, and low embryo transfer rates.

Cited by 114 publications

References 37 publications

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

Chemotherapy-induced ovarian toxicity in patients affected by endocrine-responsive early breast cancer

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Contact Info

Product

Resources

About