IVF and endometriosis-related symptom progression: insights from a prospective study

Benaglia, Laura; Somigliana, Edgardo; Santi, Giulia; Scarduelli, Claudia; Ragni, G.; Fedele, Luigi

doi:10.1093/humrep/der208

Cited by 81 publications

(62 citation statements)

References 18 publications

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“…Benaglia et al. also failed to detect any significant pain recurrence during IVF , but this series comprised only nine women with DIE, and the number of patients with bowel involvement and the criteria for conservative treatment were not specified. In addition, the nodules were quite small in size (average 10 mm).…”

Section: Discussionmentioning

confidence: 96%

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Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

Seyer‐Hansen

Egekvist

Forman

et al. 2017

Acta Obstet Gynecol Scand

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Introduction. Women with endometriosis often experience pain and infertility. Medical treatment interferes with the possibility of attaining pregnancy. For infertile women with endometriosis, surgery is a possible treatment, but with advanced disease there is an increased risk of serious complications. With only limited pain, women will often be referred for in vitro fertilization treatment instead. The disease is estrogen-dependent and during in vitro fertilization treatment the women could theoretically experience worsening of their symptoms. Material and methods. The study is a retrospective cohort study of 76 women with bowel endometriosis who were treated conservatively and underwent in vitro fertilization treatment. Results. Nine (11.8%) of the women experienced severe worsening of their bowel-related symptoms, including two patients presenting with colon ileus. One additional woman had no previous diagnosis of endometriosis before she presented with subocclusion of the bowel during in vitro fertilization. In all cases the in vitro fertilization treatment was stopped. Conclusions. Our study revealed that bowel endometriosis increases the risk of complications during in vitro fertilization treatment. This is in contrast to several publications. However, our study population is different due to the fact that none of these women had previous operations for bowel endometriosis. In all, 88% of the women completed fertility treatment without need for surgery.

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Section: Discussionmentioning

confidence: 96%

“…In accordance, early reports indicated that IVF in DIE patients can result in bowel or ureter stenosis , although the precise mechanism is unknown. Subsequent prospective studies have not provided evidence of symptomatic progression during IVF treatment , but this discrepancy could reflect less advanced disease in the study populations.…”

Section: Introductionmentioning

confidence: 96%

Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

Seyer‐Hansen

Egekvist

Forman

et al. 2017

Acta Obstet Gynecol Scand

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“…Number of COH and IVF cycles has not been associated with an increased risk of disease recurrence [46,47].…”

Section: Embryo/egg Freezingmentioning

confidence: 99%

The role of fertility preservation in patients with endometriosis

Carrillo

Seidman

Cittadini

et al. 2016

J Assist Reprod Genet

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Patients affected with severe endometriosis are at significant risk for ovarian tissue damage, which may lead to infertility, reduced response to ovarian stimulation, and occasionally, premature ovarian failure. The risk for a compromised ovarian reserve in young patients is especially high following repeated surgical intervention and in the presence of bilateral endometriomas. In many cases, enhanced loss of ovarian reserve may also result from the damaging effect of the pathologic process on follicle reservoir even without surgical interventions. Women diagnosed with severe endometriosis and those designated for extensive ovarian surgical intervention are frequently not planning to conceive. In light of recent advances in fertility preservation techniques (FPT), such as oocytes and ovarian tissue freezing, as well as their increasing success rates, we critically evaluate the options for FPT in patients suffering from endometriosis. Personalized counseling should be offered to all patients with endometriosis taking into account age, extent of ovarian involvement, current ovarian reserve, previous and impending surgeries for endometriosis, along with current success rates and possible risks associated with FPT.

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“…There is no evidence to suggest that hormonal treatment prior to IVF in those patients increases the risk of recurrence of the disease. 23 Despite the widespread use of alternative and complimentary medicine among patients with endometriosis, there are no available highquality studies to provide evidence strong enough to advise with or against the use of such remedies.…”

Section: Treatmentmentioning

confidence: 99%

An update on endometriosis associated subfertility: what does the most recent evidence say?

Abdallah

2018

Int J Reprod Contracept Obstet Gynecol

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The ENDO Study Working Group have concluded that endometriosis is probably more prevalent than previously estimated. This conclusion was derived from combining operative findings and MRI studies. 6 This is a review of the evidence published in the literature. The review was conducted via searching the databases of the Cochrane reviews, ESHRE, ACOG, NICE and BMJ best practice articles. ABSTRACTEndometriosis is a chronic debilitating disease that affects 10% of women in the reproductive age. Women with endometriosis present with pain, subfertility or both. The prevalence of endometriosis in women with subfertility is estimated to be within the range of 40%-50%. This is a review of the evidence published in the literature. The review was conducted via searching the databases of the Cochrane reviews, European Society of Human Reproduction and Embryology (ESHRE), American Society of Obstetrics and Gynaecology (ACOG), National Institute for Clinical Excellence (NICE) and British Medical Journal (BMJ) best practice articles. Management of women with endometriosis and subfertility has been extensively assessed in the literature. Medical management, surgical approaches and a combination of both improve the spontaneous pregnancy rates for this cohort of patients.

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IVF and endometriosis-related symptom progression: insights from a prospective study

Abstract: IVF does not expose women to a consistent risk of endometriosis-related symptoms progression.

Cited by 81 publications

References 18 publications

Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

The role of fertility preservation in patients with endometriosis

An update on endometriosis associated subfertility: what does the most recent evidence say?

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