Ivermectina no tratamento de camundongos (Mus muscullus) infestados por ácaros

Gressler, Lucas T.; Silva, Aleksandro Schaefer da; Sessegolo, Tayana; Bürger, Maria Ester; Monteiro, Sílvia González

doi:10.22456/1679-9216.16540

Cited by 3 publications

(2 citation statements)

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“…77,89,95 According to the authors of one study, 10 mice coinfested with fur and Demodex mites and that received ivermectin (1%; 7 μg/mL) administered in the drinking water for 5 d were cleared of all acarine parasites. 28 Whether Demodex mites were fully eradicated is unclear, because the mice were tested only once, by skin scrape at 10 d after treatment, but the exact methodology was not indicated. 28 Oral and subcutaneously administered ivermectin have been used to treat hamster demodicosis and idiopathic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…28 Whether Demodex mites were fully eradicated is unclear, because the mice were tested only once, by skin scrape at 10 d after treatment, but the exact methodology was not indicated. 28 Oral and subcutaneously administered ivermectin have been used to treat hamster demodicosis and idiopathic dermatitis. Although clinical improvement was observed in some cases, some animals required an extended treatment course, whereas others relapsed or did not show improvement.…”

Section: Discussionmentioning

confidence: 99%

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Ivermectin-compounded Feed Compared with Topical Moxidectin–Imidacloprid for Eradication of Demodex musculi in Laboratory Mice

Nashat

Arbona

Lepherd

et al. 2018

j am assoc lab anim sci

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Demodex musculi is a prostigmatid follicular mite that has rarely been reported in laboratory mice. Although prevalence of this species has not been assessed formally, we have found that many imported mouse strains from noncommercial sources harbor Demodex mites. To assess whether an acaricide can be used to eradicate this mite, infested immunocompromised mice were provided ivermectin-compounded (12 ppm) feed without restriction for 8 wk (n = 10), were treated topically with moxidectin and imidacloprid (MI; 3 and 13 mg/kg, respectively) weekly for 8 wk (n = 10), or remained untreated (n = 10). Mice were confirmed to be mite-infested before treatment and were tested after treatment by using fur plucks (FP), deep skin scrapes (DSS), and PCR analysis of fur swabs. In addition, the presence of mites was confirmed through skin biopsies at 2 study endpoints (1 wk [n = 5] and 12 wk [ n = 5] after treatment). Samples collected before treatment and from untreated mice were positive for D. musculi at all time points and by all test modalities. After treatment, all ivermectin-treated animals remained infested, whereas mice treated with MI were repeatedly negative by all test modalities. An additional shortened treatment trial revealed that 4 wk of MI (n = 7) was insufficient to eradicate mites. Neither treatment produced any evidence of adverse effects according to hematology, serum chemistry parameters, behavior, body weight, and histopathology. Of the 70 PCR assays performed in treated mice, 14 were positive when FP+DSS was negative. In 6 cases where PCR results were negative, 5 were positive by FP+DSS and a single sample was positive on skin biopsy. Although PCR analysis has a high detection rate for D. musculi, FP+DSS can further enhance the detection rate. In conclusion, topical MI administered for 8 consecutive weeks can safely eradicate D. musculi from an immunocompromised mouse strain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ivermectin-compounded Feed Compared with Topical Moxidectin–Imidacloprid for Eradication of Demodex musculi in Laboratory Mice

Nashat

Arbona

Lepherd

et al. 2018

j am assoc lab anim sci

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Two New Species ofDemodex(Acari: Demodecidae) with a Redescription ofDemodex musculiand Data on Parasitism inMus musculus(Rodentia: Muridae)

Izdebska

Rolbiecki

2015

J Med Entomol

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This article describes two new skin mite species found on the house mouse Mus musculus L., 1758. Demodex marculus sp. nov. is a very small demodecid mite (adult stages, on average, 99 µm in length) found in mouse skin in the abdomen, back, limbs, and anal area. It is characterized by relatively large bossing hammer-shaped supracoxal spines, embedded in the trapezoidal gnathosoma. Demodex fusiformis sp. nov., in turn, is a little larger (adult stages on average 111 µm in length), with a small oval gnathosoma equipped with fine, knob-like supracoxal spines. It was found in the skin of abdomen, back, and limbs. Moreover, Demodex musculi (Oudemans, 1897) was redescribed, which is small demodecid mite (adult stages on average 142 µm in length) and characterized by relatively large morphological variation and considerable sexual dimorphism. The characteristic feature of this species is the strongly elongated and rectangular gnathosoma equipped with very large wedge-shaped supracoxal spines. D. musculi was found in the skin of various, haired regions of the mice body (head, neck, abdomen, back, limbs, genital-anal region, and tail). Moreover, one more demodecid mite was found in the skin of the examined mice, it was Demodex flagellurus Bukva, 1985, which was found only in the genital area. Overall infection of Mus musculus L. by all species of Demodex was with the prevalence of 100%, mean intensity of 24.0, and range of intensity of 1-109. Despite high infection levels, no symptoms of parasitosis were observed in the hosts.

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