Ivermectin: repurposing a multipurpose drug for Venezuela's humanitarian crisis

Perez‐Garcia, Luis; Mejias-Carpio, Isis E.; Delgado-Noguera, Lourdes A.; Manzanarez-Motezuma, Jean P.; Escalona-Rodriguez, Maria A.; Sordillo, Emilia Mia; Mogollon-Rodriguez, Euler A.; Hernández‐Pereira, Carlos E.; Márquez-Colmenarez, Marilianna C; Paniz‐Mondolfi, Alberto

doi:10.1016/j.ijantimicag.2020.106037

Cited by 10 publications

(12 citation statements)

References 18 publications

(25 reference statements)

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“…A different observation on the process by which ivermectin inhibits the growth of mosquitoes when infected with P. falciparum [106]. Kobylinski et al [103] reported that ivermectin decreased the intensity and prevalence of oocyst in different mosquitoes, while de Carvalho et al and Perez-Garcia et al [104,107] reported a reduction in the prevalence of oocyst without affecting the intensity in mosquito infected with P. falciparum and P. vivax. Three different avermectins were also tested with respect to the hepatic effect of Plasmodium.…”

Section: Endectocides For Malaria Controlmentioning

confidence: 99%

Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects

et al. 2020

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Avermectins are a group of drugs that occurs naturally as a product of fermenting Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures, including ivermectin, abamectin, doramectin, eprinomectin, moxidectin, and selamectin, were isolated and divided into four major components (A1a, A2a, B1a and B2a) and four minor components (A1b, A2b, B1b, and B2b). Avermectins are generally used as a pesticide for the treatment of pests and parasitic worms as a result of their anthelmintic and insecticidal properties. Additionally, they possess anticancer, anti-diabetic, antiviral, antifungal, and are used for treatment of several metabolic disorders. Avermectin generally works by preventing the transmission of electrical impulse in the muscle and nerves of invertebrates, by amplifying the glutamate effects on the invertebrates-specific gated chloride channel. Avermectin has unwanted effects or reactions, especially when administered indiscriminately, which include respiratory failure, hypotension, and coma. The current review examines the mechanism of actions, biosynthesis, safety, pharmacokinetics, biological toxicity and activities of avermectins.

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Section: Endectocides For Malaria Controlmentioning

confidence: 99%

Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects

et al. 2020

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“…[3]. While at nanomolar concentrations it is effective mostly against nematodes, at higher concentrations, multiple new targets were identified [4,5]. Activity against various types of cancer has been reported [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Crystal Structures of New Ivermectin Pseudopolymorphs

2021

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New pseudopolymorphs of ivermectin (IVM), a potential anti-COVID-19 drug, were prepared. The crystal structure for three pseudopolymorphic crystalline forms of IVM has been determined using single-crystal X-ray crystallographic analysis. The molecular conformation of IVM in crystals has been compared with the conformation of isolated molecules modeled by DFT calculations. In a solvent with relatively small molecules (ethanol), IVM forms monoclinic crystal structure (space group I2), which contains two types of voids. When crystallized from solvents with larger molecules, like -valerolactone (GVL) and methyl tert-butyl ether (MTBE), IVM forms orthorhombic crystal structure (space group P212121). Calculations of the lattice energy indicate that interactions between IVM and solvents play a minor role; the main contribution to energy is made by the interactions between the molecules of IVM itself, which form a framework in the crystal structure. Interactions between IVM and molecules of solvents were evaluated using Hirshfeld surface analysis. Thermal analysis of the new pseudopolymorphs of IVM was performed by differential scanning calorimetry and thermogravimetric analysis.

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“…Whilst the world is witnessing a terrible humanitarian crisis in LATAM and the Caribbean with public health systems in complete chaos with an exhausted team of frontline workers, this could be a perfect scenario for promising drugs to attenuate the severe damages caused by COVID-19 [ 5 ]. Corsello et al [ 6 ] have put together an online drug-repurposing library that classifies a number of compounds from a built-in database.…”

mentioning

confidence: 99%

Ivermectin against COVID-19: The unprecedented consequences in Latin America

Molento

2021

One Health

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Ivermectin: repurposing a multipurpose drug for Venezuela's humanitarian crisis

Cited by 10 publications

References 18 publications

Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects

Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects

Crystal Structures of New Ivermectin Pseudopolymorphs

Ivermectin against COVID-19: The unprecedented consequences in Latin America

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