Ivermectin Pharmacokinetics, Metabolism, and Tissue/Egg Residue Profiles in Laying Hens

Moreno, Laura; Domínguez, Paula Revenga; Farías, Cristina Elena; Cantón, Lucila; Virkel, G.; Maté, L.; Ceballos, Laura; Lanusse, Carlos; Álvarez, Luis Ignacio Ortega

doi:10.1021/acs.jafc.5b04632

Cited by 22 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They obtained a reduction in egg count exceeding 98%, concluding that IVM can be used in antiparasitic programmes in poultry. However, the available information reporting tissue residue profiles after IVM treatment is scarce in poultry compared with other species (Goetting et al 2011;Moreno et al 2015). Edible tissues containing veterinary drug residues can pose risks to human health, including direct toxic effects, allergic reactions and increased parasites resistance (Ōmura & Crump 2014).…”

Section: Resultsmentioning

confidence: 99%

Residue depletion of ivermectin in broiler poultry

Mestorino

Buldain

Buchamer

et al. 2017

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.

show abstract

Section: Resultsmentioning

confidence: 99%

Residue depletion of ivermectin in broiler poultry

Mestorino

Buldain

Buchamer

et al. 2017

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

show abstract

“…In vertebrates, ivermectin also accumulates in fatty tissues. When ivermectin is administered to laying hens, it is preferentially deposited in the egg yolk, where residue levels were higher than those found in other tissues 30,31 .…”

Section: Discussionmentioning

confidence: 96%

Biomagnification and body distribution of ivermectin in dung beetles

Verdú

Cortez

Ortiz

et al. 2020

Sci Rep

View full text Add to dashboard Cite

A terrestrial test system to investigate the biomagnification potential and tissue-specific distribution of ivermectin, a widely used parasiticide, in the non-target dung beetle Thorectes lusitanicus (Jekel) was developed and validated. Biomagnification kinetics of ivermectin in T. lusitanicus was investigated by following uptake, elimination, and distribution of the compound in dung beetles feeding on contaminated faeces. Results showed that ivermectin was biomagnified in adults of T. lusitanicus when exposed to non-lethal doses via food uptake. Ivermectin was quickly transferred from the gut to the haemolymph, generating a biomagnification factor (BMF k) three times higher in the haemolymph than in the gut after an uptake period of 12 days. The fat body appeared to exert a major role on the biomagnification of ivermectin in the insect body, showing a BMF k 1.6 times higher than in the haemolymph. The results of this study highlight that the biomagnification of ivermectin should be investigated from a global dung-based food web perspective and that the use of these antiparasitic substances should be monitored and controlled on a precautionary basis. Thus, we suggest that an additional effort be made in the development of standardised regulatory recommendations to guide biomagnification studies in terrestrial organisms, but also that it is necessary to adapt existing methods to assess the effects of such veterinary medical products.

show abstract

“…The residues of ivermectin (IVM) and other macrocyclic lactones preferentially accumulate in the egg yolk following administration to laying hens (Keukens et al, 2000). Accordingly, it was reported that no IVM residues were found in egg white, which contains fat at trace levels, whereas significant IVM residues were measured in egg yolk, which is very rich in lipids, for 5 and 15 days following administration in water for 5 days (Moreno et al, 2015) and single oral administration (Cirak et al, 2018) of IVM, respectively, to laying hens.…”

Section: Discussionmentioning

confidence: 99%

“…SPN (spinosyn A and D) were also analyzed by HPLC with photodiode array (PDA) detector following an SPE procedure similar to the method used to analyze ABM with small modifications, as described below. Previous studies indicated that macrocyclic lactones, including ivermectin, were not detected in egg white (Keukens et al, 2000;Moreno et al, 2015;Cirak et al, 2018) after analysis of egg yolk and white separately. For this reason, only egg yolks were used for HPLC analysis.…”

Section: Analytical Proceduresmentioning

confidence: 97%

The residue levels of spinosad and abamectin in eggs and tissues of laying hens following spray application

et al. 2019

View full text Add to dashboard Cite

Spinosad (SPN) and abamectin (ABM) are used in poultry premises to control external parasites including red mites (Dermanyssus gallinae). This study aimed to determine levels of SPN (spinosyn A + spinosyn D) and ABM residues in egg and edible tissues of laying hens following spray application. A total of 36 laying hens were divided into four groups of nine birds each, and they were kept in individual cages. Two different concentrations of SPN (2 and 4 g/l) and ABM (0.025 and 0.033 g/l) were applied in stocked and empty cages, respectively. Eggs were collected individually for 30 days. All hens were sacrificed at day 30 post-treatment, and tissue samples (liver, breast muscle, fat and skin) were collected. The residue levels in eggs and tissues were determined by high pressure liquid chromatography. ABM residues were not detectable in egg samples. SPN residues in eggs and residues of both ABM and SPN in liver, muscle and fat were under the maximum residue limits (MRLs) following low and high concentration applications. However, although the MRLs have not been established for SPN and ABM in skin tissue of chicken, residues in the skin detected at the low and high concentrations were greater than the MRLs for other edible tissues (except fat tissue) indicating that a withdrawal period would be necessary for the skin tissue after ABM and SPN use in laying hens.

show abstract

Ivermectin Pharmacokinetics, Metabolism, and Tissue/Egg Residue Profiles in Laying Hens

Cited by 22 publications

References 27 publications

Residue depletion of ivermectin in broiler poultry

Residue depletion of ivermectin in broiler poultry

Biomagnification and body distribution of ivermectin in dung beetles

The residue levels of spinosad and abamectin in eggs and tissues of laying hens following spray application

Contact Info

Product

Resources

About