Ivermectin-induced bacterial gut dysbiosis does not increase susceptibility to Pseudomonas aeruginosa lung infection but exacerbates liver damage

Belo, Thiago Caetano Andrade; Santos, Natália Cristina de Melo; Souto, Bianca Silva; Rosa, Caio Pupin; Santos, Ana de Souza; Oliveira, Karen Cristina; Corsetti, Patrícia Paiva; Almeida, Leonardo Augusto de

doi:10.1016/j.micinf.2022.105080

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…For example, in a study carried out with chinchillas, the use of IVM, in the short term, did not alter the richness and diversity of the main faecal microbiota present in domestic herbivores (Firmicutes, Bacteroidetes, Verrucomicrobia, Spirochaetes and Proteobacteria) (Ma et al, 2023). These results could explain that IVM does not have a direct short‐term effect on the composition of the intestinal microbiota; however, excessive and prolonged use of IVM could lead to an imbalance in the intestinal microbiome (bacterial intestinal dysbiosis) (Andrade‐Belo et al, 2023) although the effect in terms of volatile composition is unknown.…”

Section: Discussionmentioning

confidence: 99%

Analysing the effect of ivermectin on the volatile organic compounds of dung and its possible influence on attraction to dung beetles

Urrutia,

Cortez,

Rosa‐García

et al. 2024

Ecological Entomology

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Dung odours are composed of a large number of different volatile organic compounds (VOCs). Dung beetles are attracted to dung by olfactory cues, and their selection depends on the odorous VOCs emitted from this resource. The possible effects of ivermectin (IVM) on the chemical composition of dung volatile emissions and how this could modify its attraction to dung beetles have been debated for years. In this work, we analysed the possible effects of IVM on the VOCs emitted by cattle dung and the attraction of the dung beetle Ateuchetus cicatricosus Lucas, using behavioural bioassays. The results of the study showed that the chemical analyses of the dung volatile emissions from untreated cattle, treated cattle with IVM (200 μg/kg b.w.; collected at 7 and 14 days post‐administration) and dung spiked with IVM (100 and 500 μg/kg) were not significantly different. We detected a total of 44 VOCs among the treatments. The olfactometer bioassays showed no significant difference in the rates of attraction between different treatments. This study suggests that cattle dung does not experiment with a direct modification of the volatile compounds emitted, either via the digestive tract of cattle or by direct addition with IVM, ruling out the possible influence of any transformation product from the anthelmintic that could be present. In addition, a change in the microbiota of the digestive tract in cattle as a result of the mode of action of the drug is not supported. Further possible indirect effects are discussed.

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Section: Discussionmentioning

confidence: 99%

Analysing the effect of ivermectin on the volatile organic compounds of dung and its possible influence on attraction to dung beetles

Urrutia,

Cortez,

Rosa‐García

et al. 2024

Ecological Entomology

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Differential Effects of Two Common Antiparasitics on Microbiota Resilience

Doolin,

Dearing

2023

The Journal of Infectious Diseases

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Background Parasitic infections challenge vertebrate health worldwide, and off-target effects of antiparasitic treatments may be an additional obstacle to recovery. However, there have been few investigations of the effects of antiparasitics on the gut microbiome in the absence of parasites. Methods We investigated whether two common antiparasitics—albendazole (ALB) and metronidazole (MTZ)—significantly alter the gut microbiome of parasite-free mice. We treated mice with ALB or MTZ daily for 7 days and sampled the fecal microbiota immediately before and after treatment and again after a two-week recovery period. Results ALB did not immediately change the gut microbiota, while MTZ decreased microbial richness by 8.5% and significantly changed community structure during treatment. The structural changes caused by MTZ included depletion of the beneficial family Lachnospiraceae, and predictive metagenomic analysis revealed that these losses likely depressed microbiome metabolic function. Separately, we compared the fecal microbiotas of treatment groups after recovery, and there were minor differences in community structure between the ALB, MTZ, and sham-treated control groups. Conclusions These results suggest that a healthy microbiome is resilient after MTZ-induced depletions of beneficial gut microbes, and ALB may cause slight, latent shifts in the microbiota but does not deplete healthy gut microbiota diversity.

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Ivermectin-induced bacterial gut dysbiosis does not increase susceptibility to Pseudomonas aeruginosa lung infection but exacerbates liver damage

Cited by 2 publications

References 37 publications

Analysing the effect of ivermectin on the volatile organic compounds of dung and its possible influence on attraction to dung beetles

Analysing the effect of ivermectin on the volatile organic compounds of dung and its possible influence on attraction to dung beetles

Differential Effects of Two Common Antiparasitics on Microbiota Resilience

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