Ivermectin in dermatology: why it ‘mite’ be useless against COVID‐19

Is there any prophylactic role for ivermectin in COVID‐19—A literature summary

“…Dear Editor, While there are different regimens and opinions that define the role of ivermectin (IVM) in COVID-19 (Table 1), [1][2][3][4] an interesting and often ignored concept is the administeration of prophylactic IVM, which has been found to have serendipitously been effective in a hospital setting during the COVID-19 pandemic. 2 This concept mirrors the prescription practices of clinicians in COVID-19 hit countries, even though others believe that firm data on the drug are awaited.…”

“…2 This concept mirrors the prescription practices of clinicians in COVID-19 hit countries, even though others believe that firm data on the drug are awaited. 3 While purists wait for a double-blind randomized control trial (DB RCT), this is difficult in real-life practice where multiple drugs are administered to patients in real-life settings. 5 We would like to counter the persistent refrain that echoes the belief that there are no enough data on IVM, 3 and our exhaustive search for the published data on PubMed has found numerous drug-dosed studies in COVID-19 using ivermectin (IVM), which decry this constant refrain.…”

“…4 (Table 1). [1][2][3][4] While there are various steps that determine the efficacy of the drug in COVID-19, which includes in silico proof, in vitro experiments and in vivo studies, the clinical efficacy of any drug depends largely on the stage of the disease and its severity. It is obvious that the primary action of IVM is of a potential antiviral drug, and thus, its efficacy would be in the first 12 days of the disease or the early stage of diagnosis.…”

Development and validation of ivermectin quantification method in volumetric absorptive microsampling using liquid chromatography-tandem mass spectrometry

“…In 2020, the antiviral properties of ivermectin against SARS-Cov-2 was found in-vitro [ 12 ]. In this study, ivermectin in vitro was able to inhibit the transfer of ribonucleic acid (RNA) of the SARS-CoV-2 virus five thousand times at a concentration of 5 M within 48 h [ [11] , [12] , [13] , [14] ]. However, the concentration needed to be able to reduce viral RNA is toxic because very high doses are needed as an antiviral [ 15 , 16 ].…”