Ivermectin As An Antiparasitic Agent For Use In Humans

Simuliid blackflies (Diptera: Simuliidae) and ceratopogonid midges (Diptera: Ceratopogonidae) as vectors of Mansonella ozzardi (Nematoda: Onchocercidae) in northern Argentina

“…Little is known about the effects of ivermectin on this parasite (Campbell 1991), except that Nutman et al (1987) in a comprehensive study on one infected individual observed that microfilariae had disappeared from the blood for a nine month period following a single treatment with ivermectin (140 µg/kg body weight). It is probable that the drug had suppressed production of microfilariae for this period but not killed the female worm, as occurs in onchocerciasis.…”

The Role of Endosymbiotic Wolbachia Bacteria in the Pathogenesis of River Blindness

“…Ivermectin, a macrocyclic lactone [110] acts through inhibition of glutamate-gated chloride channels of microfilariae, effectively immobilizing them. It rapidly reduces the number of skin microfilariae, but depletes them only for a few months, after which they reappear at amounts of 20% or more of pretreatment levels within a year [111].…”

Microfilariae recurrence in graded murrah buffalo treated with repeated doses of ivermectin

“…However, it is still not certain why ivermectin shows activity only against microfilaria and but not on adult worms (Campbell 1991). It is confirmed in loaosis patients with ultrasonography that, the adult worms are not killed even at total doses of 4,800 lg/kg bodyweight over a period of 6 months (Dreyer et al 1996).…”