Ivermectin antiviral activity against Varicellovirus bovinealpha 1: assessment of intracellular drug accumulation in virus-infected cells

Pérez, Sandra; Miró, María Victoria; Verna, Andrea; Altamiranda, Erika Gonzalez; Barcos, Oscar; Lanusse, Carlos; Lifschitz, Adrian

doi:10.1007/s00203-023-03806-3

Cited by 1 publication

(1 citation statement)

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“…Through this mechanism, ivermectin may have antiviral effects on viruses that rely on this interface, such as human immunodeficiency virus-1 (HIV-1), dengue (DENV), Zika (ZIKV), West Nile virus (WNV), Venezuelan equine encephalitis virus, chikungunya, and SARS-CoV-2 (COVID-19) [58]. Furthermore, ivermectin has been shown in some studies to be an inhibitor of viral replication [59][60][61][62]. The below section will focus on the contentious use of ivermectin in the management of COVID-19 and its application in the treatment of human adenoviruses.…”

Section: Antiviral Activitymentioning

confidence: 99%

Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy

Kaur,

Blavo,

Parmar

2024

Cureus

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Ivermectin was first discovered in the 1970s by Japanese microbiologist Satoshi Omura and Irish parasitologist William C. Campbell. Ivermectin has become a versatile pharmaceutical over the past 50 years. Ivermectin is a derivative of avermectin originally used to treat parasitic infections. Emerging literature has suggested that its role goes beyond this and may help treat inflammatory conditions, viral infections, and cancers. Ivermectin's anti-parasitic, anti-inflammatory, anti-viral, and anticancer effects were explored. Its traditional mechanism of action in parasitic diseases, such as scabies and malaria, rests on its ability to interfere with the glutamate-gated chloride channels in invertebrates and the lack of P-glycoprotein in many parasites. More recently, it has been discovered that the ability of ivermectin to block the nuclear factor kappa-light-chain enhancer of the activated B (NF-κB) pathway that modulates the expression and production of proinflammatory cytokines is implicated in its role as an anti-inflammatory agent to treat rosacea. Ivermectin has also been evaluated for treating infections caused by viruses, such as SARS-CoV-2 and adenoviruses, through inhibition of viral protein transportation and acting on the importin α/β1 interface. It has also been suggested that ivermectin can inhibit the proliferation of tumorigenic cells through various pathways that lead to the management of certain cancers. The review aimed to evaluate its multifaceted effects and potential clinical applications beyond its traditional use as an anthelmintic agent.

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