Ivermectin: An update

Campbell, William C.

doi:10.1016/0169-4758(85)90100-0

Cited by 229 publications

(113 citation statements)

References 12 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…One possibility may be that in viuo, subcutaneously injected ivermectin has less access to N.amer~ca~us than to worms of other hookworm genera and in this context A.duodenale generally penetrate deeper into the gut mucosa than N.americanus (see Bonne, 1942;Zimmerman, 1946). Furthermore, A.duodenaIe is known to cause more profound blood loss than N.americanus in humans (Roche & Layrisse, 1966) but in our system A.ceylanicum is comparably the more pathogenic (Behnke, 1991 1985;Henriques, Martin & Sievers, 1985;Campbell, 1989) which cause only minimal blood loss and are regarded as mucosal surface browsers, are sensitive to subcutaneously administered ivermectin at doses of < 50 pg kg-'.…”

Section: Discussionmentioning

confidence: 81%

“…Although it was originally widely believed that the principal target of ivermectin was GABA mediated transmission of signals to longitudinal muscles (Campbell, 1985) the exact mode of action is now disputed. The physiological effect of ivermectin is an increase in permeability of cell membranes to chloride ions (Turner & Schaeffer, 1989) and it has recently been proposed that a novel Cl -channel may be the receptor (reviewed Geary, Klein, Vanover, Bowman & Thompson, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…of ivermectin, in 1981 as an antiparasitic drug for helminths and arthropods has had a marked impact on the treatment of animal diseases and recently, following successful trials in humans, a licence has been granted for treatment of patients with onchocerciasis (Campbell, 1985;Green, Brown & Taylor, 1989). Many of the common gastrointestinal nematodes are highly susceptible to ivermectin, at concentrations measured in pg kg-' body weight, considerably smaller than the mg kg-' concentrations required for effective antiparasite activity of other anthelmintics.…”

Section: The Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus

Behnke

Rose

Garside

1993

International Journal for Parasitology

View full text Add to dashboard Cite

AbStrBCt-BEHNKEJ.M., ROSE R. and GARSIDE P. 1993. Sensitivity to ivermectin and pyrantel of Ancylosioma ceylanicum and Necator americanus. International Journal for Parasitology 23: 945-952. Experiments were carried out in the hamster to compare the relative susceptibility of Necator americanus and Ancylostoma ceylunicum to treatment with ivermectin. A.ceylanicum was found to be 300 times more sensitive to the anthelmintic with a 50% effective dose (ED,,) of the order of lo-15pg kg-' body weight whilst that for N.americanus approximated to 3-5 mg kg-'. Furthermore, whereas complete clearance of A.ceylunicum was observed with a dose of lOOfig kg-', Namericunus was not totally removed after treatment with 25 mg kg-', the highest dose tested. Both parasites proved equally sensitive to pyrantel with an ED,, of 1-12 mg kg-' for A.ceylanicum and 5-25 mg kg-' for N.americanus. Treatment with pyrantel at 1OOmg kg-' completely eliminated worms of both species and doses of 25-50 mg kg-' were > 90% effective. In addition to worm burdens, changes in host weight and PCV were also recorded and it was shown that both parameters could be used to evaluate the success/failure of treatment.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: The Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus

Behnke

Rose

Garside

1993

International Journal for Parasitology

View full text Add to dashboard Cite

show abstract

“…pdf) while Merck, the original manufacturer of ivermectin, defined it as being composed of 'at least 80%' of 1 and 'not more than 20%' of 2. 21 Such possible minute variations, which could lead to differing amounts of the molluscicidal minor component 2 in commercially available products, might account for differences in the potency of IVM tested against snails by different researchers.…”

Section: Discussionmentioning

confidence: 99%

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis

et al. 2017

View full text Add to dashboard Cite

The impact of ivermectin on adult snails of the genus Biomphalaria (B. glabrata, B. tenagophila and B. straminea), B. glabrata infected with Schistosoma mansoni, snail egg-masses cercariae and miracidia, as well as on guppy fish (Poecilia reticulata) was examined and evaluated. Biomphalaria snails, egg-masses, parasite stages and guppies were all exposed to different concentrations of ivermectin for 24 h, followed by regular observations of mortality. The calculated lethal doses of ivermectin were around an LD 50 of 0.03 μg ml − 1 , and an LD 90 of 0.3 μg ml − 1 for the three species of snails. Specimens of B. glabrata actually shedding parasite cercariae all died when exposed to ivermectin at a concentration of a mere 0.01 μg ml − 1 . Ivermectin B 1a , the major (80%) component of commercially available ivermectin, proved to be inactive, and it was the minor (20%) component, ivermectin B 1b , which caused snail death. Snail egg-masses were not affected, even at the highest concentration of 100 μg ml − 1 . With respect to S. mansoni parasite stages, 0.2 μg ml − 1 ivermectin killed 50% of cercariae and miracidia within five minutes, rising to 90% after 30 min. Mortality of guppy fish within 24 h of exposure to ivermectin at concentrations of 0.5 μg ml − 1 and 0.01 μg ml − 1 , were 100% and 30%, respectively. The concentration of 0.01 μg ml − 1 that killed Schistosoma mansoni-infected snails only caused 30% mortality in guppy fish. Ivermectin can be considered a promising molluscicide, especially as it is more potent against infected snails than uninfected ones, although it has no impact on egg-masses. Ivermectin and its derivatives could be explored in the search for a new agent to help control schistosomiasis transmission.

show abstract

“…Ivermectin is a complex macrocyclic lactone which possesses a broad spectrum of activity against several species of nematodes, arachnids, and insects that act as parasites. Ivermectin, known for its relatively high potency and low toxicity, is commonly used for heartworm control in dogs as well as the treatment of various tropical diseases such as onchocerciasis or "river blindness" in humans (9). Our previous studies with Rose, J.M., Peckham, S.L., Scism, J.L., and Audus, K.L.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Rose

Peckham

Scism

et al. 1998

Neurochemical Research

View full text Add to dashboard Cite

Evaluation of the role of P-glycoprotein in ivermectin uptake by primary cultures of bovine brain microvessel endothelial cells. Neurochem. Res. 23,[203][204][205][206][207][208][209] Keywords: brain microvessel endothelia; blood-brain barrier; P-glycoprotein; rhodamine 123; ivermectin Abstract: The P-glycoprotein efflux system located on the apical membrane of brain capillary endothelial cells functions as part of the blood-brain barrier. In this study, primary cultures of bovine brain microvessel endothelial cells (BMECs) were investigated for the presence of a Pglycoprotein system and its contribution in regulating ivermectin distribution across the bloodbrain barrier. Results of rhodamine 123 uptake studies with cyclosporin A and verapamil as substrates indicated that a functional efflux system was present on BMECs. Immunoblot analysis with the C219 monoclonal antibody to the product of the multidrug resistant member 1(MDR1) gene also confirmed the expression of MDR1 in the BMECs. Unbound ivermectin was shown to significantly increase the uptake of rhodamine 123 in BMECs, however, the drug only modestly enhanced the transcellular passage of rhodamine. The results of these studies affirmed that unbound ivermectin is an inhibitor of the MDR1 efflux system in BMECs. Text of paper:Rose, J.M., Peckham, S.L., Scism, J.L., and Audus, K.L. (1998) Evaluation of the role of P-glycoprotein in ivermectin uptake by primary cultures of bovine brain microvessel endothelial cells. Neurochem. Res. 23,[203][204][205][206][207][208][209]

show abstract

Ivermectin: An update

Cited by 229 publications

References 12 publications

Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus

Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis

Untitled

Contact Info

Product

Resources

About