Ivermectin ameliorate the toxic effect of dimethylhydrazine in male Wistar rats

Al-Zharani, Mohammed; Alghamdi, Hamzah A.; Aldahmash, Badr Abdullah; Elnagar, Doaa M.; Alhoshani, Norah M.; AL–Johani, Norah S.; Alkeraishan, Nora; Alhenaky, Alhanof; Aljarba, Nada H.; Alahmari, Abeer; Alkahtani, Saad

doi:10.1016/j.jksus.2022.102349

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…Heart sections in rat treated with 10 and 20 mg/kg DMH shows edema, Zenker's necrosis, discontinuation of muscle fibers with foci of infiltration of inflammatory cells and hemorrhage but more sever lesions in dose 20 mg/kg some studies indicated that there are a vasoconstriction occur in the coronary vessels of heart after Acute exposure to DMH (20), heart lesions occurs because of toxic effect of DMH and free radicle that release whereas DMH needs bio activations to induce its mutagenic effects and induce its hepatotoxic effects so its activated metabolically in liver by several steps of reactions to carcinogenic and toxic metabolite through intermediates methylazoxymethanol and azoxymethane and these metabolite affect cardiac muscles and cause cardiomyopathies (18,36,37).because of DMH is a potent colonic and hepatic carcinogen many tumors that occur in colon cause release of H2O2 which is under go detoxification in liver and distributed in all tissues by circulation including heart and many generations of H2O2 are produced from this tumors thus induce cardiomyopathies and continuous injury to rat tissues (38,39). Kidneys sections in rats treated with10 and 20 mg/kg DMH for 8 weeks reveals vacuolar degeneration of epithelial lining renal tubules with cloudy swelling and hyaline casts in some lumen of renal tubules because of application of hydrazine derivates is nephrotoxic and leads to an impairment in renal tubules, decreasing glomerular filtration rate and function (11,40,41), a numbers of animals studies on hydrazine and it derivatives are hypothesized that toxicity is exerted by interfering in urea cycle this occurred by increased levels Nα-acetyl citrulline and arginosuccinate (42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of lesions induced by dimethyl hydrazine in male rats

Al-Hamdany¹,

Al-Mallah²,

Ismail³

2022

IJVS

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This study evaluated dimethylhydrazines' carcinogenic and toxic effect (DMH) in male rats; 30 albino rats were divided into three groups, randomly ten rates for each one. Group 1 control group was lifted for water only, group 2 was treated with DMH at a dose of 10 mg /kg bw in 0.9% sodium chloride subcutaneously once weekly for eight weeks, and group 3 was treated with DMH at a dose of 20 mg /kg bw in 0.9% NaCl subcutaneously once weekly for eight weeks. Liver grossly congested with pinpoint hemorrhage in a dose of 10 mg/kg of bw and enlarged in a dose of 20 mg/kg bw. Congestion of blood vessels in the heart with hypertrophy of myocardium in a dose of 20 mg/kg bw. Kidney grossly appears normal in both doses. Lesions of the liver treated with DMH in the dose 10 mg/kg BW show discontinuation of hepatocytes, infiltrations of inflammatory cells, and vacuolar degeneration of hepatocytes with apoptotic bodies. Section of the liver treated with DMH in the dose 20 mg/kg BW shows acute hemorrhage and focal necrosis of hepatocytes with edema. Heart treated with DMH in a dose of 10 mg/kg BW shows discontinuation of myocardial muscle fibers and infiltrations of inflammatory cells. In contrast, lesions in the dose 20 mg/kg bw show foci of inflammatory cells with cardiomyopathies of myocardium and congestion of blood vessels. Kidney treated with DMH in a dose of 10 mg/kg BW shows degeneration of epithelial cells lining renal tubule, infiltrations of inflammatory cells, hyaline cast with atrophy of glomerular tuft, increased space of Bauman's, and cloudy swelling. The kidney section treated with DMH in a dose of 20 mg/kg bw shows hemorrhage between renal tubules, congestion of blood vessels, infiltrations of inflammatory cells, a renal cyst, and degeneration of glomeruli.

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Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of lesions induced by dimethyl hydrazine in male rats

Al-Hamdany¹,

Al-Mallah²,

Ismail³

2022

IJVS

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“…However, each model system has limitations, and as of this writing (April 2020), no documented animal model of SARS-CoV-2 infection entirely reproduces every critical trait of severe COVID-19 infection. Recently, it has been reported that IVM is widely used for prophylaxis and associated with a reduction of SARS-CoV-2 infection among healthcare workers for weeks (Al-Zharani et al, 2022). Hence, the present study aimed to assess the pathophysiological effects of Ivermectin on the Hematological and biochemical parameters in normal albino rats after six weeks.…”

Section: Introductionmentioning

confidence: 94%

A Novel Study on the Hematological and Physiological Disturbance of Ivermectin-COVID 19 Treatment Abuse in Male Wistar Rats

Haroun

Bashandy

Hussein

2023

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Background: During COVID-19 and reported prevalence of self-medication practices dup to 88.35 % of the overall population which included mainly acetaminophen, antibiotics, chloroquine and ivermectin. Pointless prophylaxis, prevention and treatment protocols for COVID-19 pushed people to adopt selfmedication and more concerning, self-dosing without prescription. The present study was designed to detect the therapeutic effect of COVID-19 treatment protocols (ivermectin) followed by the administration of lactoferrin on biochemical as well as haematological parameters in experimental Albino rats. Material and Methods: Thirty adult male albino rats were carried out in the present study; rats were randomly assigned to different control and treatment groups. The experimental groups in common were divided into three groups (Each group have10 rats) as the following: Group I: Rats received saline solution orally); Group II: Rats Ivermectin intraperitoneal (ip) at (15 mg/kg B.W) at a single dose weekly for 6 weeks; Group III: Rats administrated to Ivermectin intraperitoneal (ip) at (15 mg/kg B.W) followed by treatment of Lactoferrin per orally for 6 weeks. Blood samples were collected under diethyl ether anaesthesia for further determination of hematological and biochemical parameters. Results: Following the present results, the administration of therapeutic ivermectin produced alterations in some biochemical parameters which correlated with hematological parameters in the positive untreated group as compared to the normal control group. In contrast, a group of rats administrated lactoferrin caused a reduction in urea, and creatinine levels in the positive treated group in comparison to the positive untreated group. Consequently, it could be concluded that it is not preferable to use ivermectin, particularly without any recommendation or evidence of parasitic exposure while lactoferrin need to be used for prophylaxes prior to oral intake in need.

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Ivermectin ameliorate the toxic effect of dimethylhydrazine in male Wistar rats

Cited by 2 publications

References 31 publications

Histopathological evaluation of lesions induced by dimethyl hydrazine in male rats

Histopathological evaluation of lesions induced by dimethyl hydrazine in male rats

A Novel Study on the Hematological and Physiological Disturbance of Ivermectin-COVID 19 Treatment Abuse in Male Wistar Rats

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