Ivermectin: A multilevel approach to evaluate effects in Prochilodus lineatus (Valenciennes, 1836) (Characiformes, Prochilodontidae), an inland fishery species

Lozano, Ismael Esteban; Piazza, Yanina Grisel; Babay, Paola Alejandra; Sager, Emanuel; Torre, Fernando R. de la; Nostro, Fabiana Laura Lo

doi:10.1016/j.scitotenv.2021.149515

Cited by 12 publications

(3 citation statements)

References 79 publications

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“…Hematological analyzes can be used as indicators of the health status of fish, allowing the detection of morbid conditions (Oliveira et al, 2022). Treatment with ivermectin did not result in harmful changes in red blood cells profile of tilapia, corroborating the findings of Lozano et al (2021) who studied ivermectin in Prochilodus lineatus (Curimbatá) exposed to environmental concentrations at doses of 0.5 and 1.5 μg L −1 . Madrid et al (2021) observed a decrease in red blood cell counts in Amazonian fish (Corydoras schwartzi) 7 days post-treatment with a dose of 860 µg mg of ivermectin/kg, although the averages observed were around half the value found for the control fish, these findings were not statistically significant when compared to control fish.…”

Section: Discussionsupporting

confidence: 72%

CLINICAL SAFETY OF IVERMECTIN TREATMENT IN NILE TILAPIA, Oreochromis niloticus

SILVA,

OLIVEIRA,

COSTA

et al. 2023

Ars Vet

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Ivermectin belongs to the group of avermectins, a group of macrocyclic lactones produced by Streptomyces avermitilis, this drug is widely used in the treatment of endoparasitoses and ectoparasitosis in different species of mammals around the world. Based on this need to develop an adequate sanitary management of fish farms and the therapeutic importance of macrocyclic lactones, this study aimed to evaluate the clinical safety of ivermectin administered orally as part of the feed for Nile tilapia (O. niloticus). For this, 56 tilapias (O. niloticus), ±100g, were placed in 7 aquariums (n=8) with a capacity of 100 L of water, supplied with running water devoid of chlorine, with the following treatments being preserved: T0 (Control, untreated), T1 and T2 (treated with 125 and 625µg/kg-1 of ivermectin, respectively). Blood samples were collected for hemogram, leukogram and evaluation of serum biochemical parameters, in addition to organs such as spleen, liver and kidneys (cranial and caudal) for somatic evaluation. The results admired an increase in serum levels of ALT, AST and glycemia, a reduction in cholesterol and triglyceride values at the highest dose, in addition to a decrease in total protein levels and liver somatic analysis. There was no change in hematological parameters, while the leukocyte profile indicated a significant increase in total leukocytes in treated tilapia with lymphocytosis and neutrophilia.. Therefore, treatment with high doses of ivermectin can harm the health of Nile tilapia, requiring additional studies to establish safe therapeutic protocols for these animals.

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Section: Discussionsupporting

confidence: 72%

CLINICAL SAFETY OF IVERMECTIN TREATMENT IN NILE TILAPIA, Oreochromis niloticus

SILVA,

OLIVEIRA,

COSTA

et al. 2023

Ars Vet

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“…In Table 1 the parameters employed for the calculation and their corresponding limits are presented. The WQI categorization was very poor (0-29), poor (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44), marginal (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64), bad (65-79), good (80-94), and excellent (95-100).…”

Section: Data Analysesmentioning

confidence: 99%

“…Ivermectin (IVM) is primarily one of the most widely used antiparasitics worldwide (Lorente et al, 2023), administered to livestock such as cattle, sheep, horses, and pigs, functioning as both an endo-and ectoparasiticide. Up to 80-90% of the administered dose is excreted unaltered in the dung of the treated animal (Lozano et al, 2021). Information about the presence of veterinary pharmaceutical in the environment is scarce (Ramirez-Morales et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Impacts of cattle management and agricultural practices on water quality through different approaches: physicochemical and ecotoxicological parameters

Peluso,

Chehda,

Olivelli

et al. 2023

Preprint

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The intensification of livestock farming can pose risks to the environment due to the increased use of veterinary products and the generation of waste in confined areas. The quality of water bodies near livestock establishments (Areco river (A) and Doblado stream (D), San Antonio de Areco, Buenos Aires, Argentina) was studied by physicochemical parameters, metals, pesticides, emerging contaminants, and lethal and sublethal toxicity (neurotoxicity and oxidative stress) in larvae of the native amphibian Rhinella arenarum. Six sites were selected: upstream (S1A and S1D), at the level of (S2A and S2D), and downstream (S3A and S3D) from the establishments. A low concentration of dissolved oxygen was observed in Doblado stream (<2.34 mg/L). Cu, Mn, V, and Zn exceeded the limits for the protection of aquatic life at various sites. Between 24 and 34 pesticides were detected in all sites, with 2,4-D, atrazine, and metolachlor being the most recurrent. In water and sediment, the concentrations of ivermectin (S2A: 1.32 μg/L and 58.18 μg/kg; S2D: 0.8 μg/L and 85.22 μg/kg) and oxytetracycline (S2A: <1 mg/L and <1 mg/kg; S2D: 11.8 mg/L and 39 mg/kg) were higher at sites near the establishments. All sites caused between 30 and 38.3% of lethality and produced neurotoxicity and alterations in the reduced glutathione content. Also, larvae exposed to samples from all sites incorporated ivermectin. These results demonstrate the degradation of the studied sites in relation to the agricultural activities of the area, highlighting the need to take measures to protect and preserve aquatic ecosystems.

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