Long standing oral cavity lesions may have malignant behavior, one of the premalignant condition is like verrucous hyperplasia of tongue having diverse histopathological structures. Now a days treating such lesion with an ayurvedic management is biggest challenge, ayurvedic medicines and local treatment has got potential to reduce severity of such diseases. One such case of verrucous hyperplasia of tongue has been treated by us with ayurvedic management since last six months and got enthusiastic results. Hence it is necessary that entire disciplinary approach can be fruitful in such disorders.