Ivabradine in Patients With Symptomatic Inapprioprate Sinus Tachycardia: Long-Term Observational Study

Ptaszyński, Paweł; Kaczmarek, Krzysztof; Cygankiewicz, Iwona; Klingenheben, Thomas; Urbanek, Irmina; Wranicz, Jerzy Krzysztof

doi:10.1016/s0735-1097(17)33695-1

Cited by 2 publications

(6 citation statements)

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“…Heart rate reduction with ivabradine was lowest in studies that included patients with baseline HR values below the diagnostic criteria for IST 13,17 . Significant HR reduction was observed as early as 1 week and persisted for as long as 5 years 16,24 . Although the HR reductions were significant, mean HRs achieved did not fall below one or more of the IST criteria at the conclusion of three of the studies 21–23 .…”

Section: Resultsmentioning

confidence: 96%

“…One study reported qualitative improvement in functional class, whereas another study did not observe a significant improvement in exercise tolerance 18,19 . Symptomatic control of IST or quality of life were reported in 11 studies, all reporting improvement with ivabradine 13,15,17–24,27 . In two separate studies, complete resolution of symptoms at end of the study were reported in 100% and 74% of patients, respectively 15,24 .…”

Section: Resultsmentioning

confidence: 99%

“…Symptomatic control of IST or quality of life were reported in 11 studies, all reporting improvement with ivabradine 13,15,17–24,27 . In two separate studies, complete resolution of symptoms at end of the study were reported in 100% and 74% of patients, respectively 15,24 . Ivabradine was associated with greater symptom resolution than placebo and fewer symptomatic events compared to β‐blockers 13,22,27 …”

Section: Resultsmentioning

confidence: 99%

“…Our search revealed 16 studies evaluating ivabradine for the treatment of IST in 383 adults (Table 1). 13–28 The majority of these studies (13) were observational cohort studies 14–21,23–26,28 . Only five studies utilized a control or comparator group 13,21,22,27,28 .…”

Section: Resultsmentioning

confidence: 99%

“…Ivabradine also appeared to be effective at improving exercise tolerance and symptoms in adults with IST (Table 1). Eight studies reported data on various measures of exercise tolerance, five reported objective evidence of significant improvement 13,16,18,19,21–24 . One study reported qualitative improvement in functional class, whereas another study did not observe a significant improvement in exercise tolerance 18,19 .…”

Section: Resultsmentioning

confidence: 99%

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Beyond Heart Failure and Ischemic Heart Disease: A Scoping Review of Novel Uses of Ivabradine in Adults

2020

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Ivabradine lowers heart rate by inhibiting the hyperpolarization-activated current in pacemaker cells, and its use for the treatment of heart failure (HF) and ischemic heart disease (IHD) is well described. Ivabradine may be an attractive treatment option for other conditions for which a reduction in heart rate is desirable but less is known about its role in these settings. The primary objective was to perform a scoping review summarizing the literature evaluating novel uses for ivabradine other than HF and IHD in adults. PubMed and EMBASE were searched for articles for all dates through September 2019. Search strategies combined terms generic, commercial/trade, and international names for ivabradine. Manual search of references was also performed to identify additional articles. Studies were included if they were published in English, evaluated the efficacy of ivabradine for indications other than HF or IHD in patients aged 18 years or older, and the primary outcome included clinically relevant end points. Articles were screened first by title and abstract followed by full-text screening of the remaining articles. After removal of duplicates, 1807 records were screened for inclusion and 84 studies were included in this scoping review. Novel uses of ivabradine were reported for various tachyarrhythmias, valvular heart disease, premedication for coronary computed tomography angiography, perioperative risk reduction, sepsis with and without multi-organ dysfunction syndrome, cor pulmonale, reactive airway disease, and erectile dysfunction. This scoping review identified several potential novel uses for ivabradine in adults. This review may help to identify existing gaps where further research is needed to elucidate the role of ivabradine for indications beyond HF and IHD. KEY WORDS ivabradine, tachycardia, asthma, CT angiography, perioperative risk reduction, pulmonary hypertension, multi-organ dysfunction syndrome, valvular heart disease.

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Section: Resultsmentioning

confidence: 96%