Ivabradine for congenital junctional ectopic tachycardia in siblings

Ss, Kothari; Kidambi, Bharath Raj; Juneja, Rajnish

doi:10.4103/apc.apc_25_18

Cited by 11 publications

(13 citation statements)

References 6 publications

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“…[ 9 ] Digoxin, amiodarone, propranolol, and flecainide have been used alone or in combination. [ 9 10 11 12 ] More recently, ivabradine, the selective and specific inhibitor of the cardiac pacemaker current (If), has been found useful in resistant cases. [ 12 13 ] Successful transcatheter ablation has been reported with preservation of normal AV conduction and is suggested for drug refractory cases.…”

Section: Congenital Junctional Ectopic Tachycardiamentioning

confidence: 99%

“…[ 9 10 11 12 ] More recently, ivabradine, the selective and specific inhibitor of the cardiac pacemaker current (If), has been found useful in resistant cases. [ 12 13 ] Successful transcatheter ablation has been reported with preservation of normal AV conduction and is suggested for drug refractory cases. [ 10 14 15 16 17 18 19 ] A few cases of sudden death have been attributed to evolution to complete heart block, unrelated to ablation procedures.…”

Section: Congenital Junctional Ectopic Tachycardiamentioning

confidence: 99%

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Diagnosis and management of junctional ectopic tachycardia in children

Sasikumar¹,

Kumar

Balaji

2021

Ann Pediatr Card

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Junctional ectopic tachycardia (JET) is more common in its postoperative form. A thorough understanding of its etiology, pathophysiology, and management strategies is essential. Classically, postoperative JET is considered to arise from surgical trauma. Genetic susceptibility and an intrinsic morphologic/functional defect in the conduction system inherent in congenital heart diseases likely play a significant role. The devastating effects on postoperative hemodynamics warrant prompt attention. A multipronged management approach with general measures, pharmacotherapy, and pacing has decreased morbidity and mortality. Amiodarone and procainamide remain the preferred drugs, while ivabradine appears promising. Carefully planned randomized trials can go a long way in developing a systematic management protocol for postoperative JET.

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Section: Congenital Junctional Ectopic Tachycardiamentioning

confidence: 99%

Section: Congenital Junctional Ectopic Tachycardiamentioning

confidence: 99%

Diagnosis and management of junctional ectopic tachycardia in children

Sasikumar¹,

Kumar

Balaji

2021

Ann Pediatr Card

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“…It is widely used to decrease sinus rate in the treatment of cardiac failure [ 12 , 13 ]. Recently, it has also been described to successfully treat JET in children with rapid rate control and establishment of sinus rhythm [ 14 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Kothari et al reported two siblings with CJET unsatisfactory controlled with multiple antiarrhythmic agents, including propranolol, flecainide and amiodarone, and significantly converted to sinus rhythm after the first dose of ivabradine [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review

et al. 2021

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Congenital junctional ectopic tachycardia (CJET) is a rare tachyarrhythmia that remains difficult to manage, with suboptimal control in most cases. Here, we report literature research on the use of ivabradine in the treatment of pediatric junctional ectopic tachycardia (JET), both congenital and postoperative, and describe the successful use of ivabradine–flecainide association for CJET therapy resistant to other antiarrhythmic agents. This new drug combination was effective in completely suppressing JET. Ivabradine–flecainide combination may be considered a new therapeutic strategy of CJET with a satisfactory efficacy/tolerability ratio in patients resistant to conventional drug combinations.

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“…[ 3 ] However, ivabradine is seldom used as the first-line agent. [ 4 ] We report a neonate with congenital JET who reverted to sinus rhythm with ivabradine monotherapy.…”

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confidence: 99%