Iv Busulfan Administered Q12 Vs Q6 Hrs During Conditioning of Pediatric Allogeneic Stem Cell Transplant (AlloSCT) Recipients Has Comparable Pharmacokinetics and Significant Reduction in Nursing/Pharmacist Costs

LeGall, J.B.; Milone, Michael C.; Waxman, Ian M.; Shaw, Leslie M.; Harrison, Lauren; Duffy, Deirdre; Militano, Olga; Bhatia, Monica; Satwani, Prakash; George, Diane; Garvin, James H.; Bradley, M.B.; Ven, Carmella van de; Cairo, Mitchell S.

doi:10.1016/j.bbmt.2010.12.317

Cited by 1 publication

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“…The V d , t 1/2 and CL n for that cohort were 20.6 ± 16.6 L, 132.0 ± 31.1 min, 3.6 ± 0.9 mL/min/kg, respectively. 12 As expected, the AUC for a single dose of q12 h BU is approximately double that of q6 h i.v. BU (1077±352 mmol Â min/L).…”

Section: Discussionmentioning

confidence: 72%

“…BU (1077±352 mmol Â min/L). 12 When q12 h and q6 h i.v. BU AUC are converted to C ss , total BU exposure is comparable-q12 h mean C ss : 687 ng/mL vs q6 h mean C ss : 736 ng/mL.…”

Section: Discussionmentioning

confidence: 99%

“…BU PK in pediatric allo-SCT recipients. 10,12 With the same total daily dose, q12 h i.v. BU recipients have comparable V d , t 1/2 and CL n with q6 h i.v.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously described a cohort of q6 h i.v. BU recipients PK, 12 with PK performed at the University of Pennsylvania. The V d , t 1/2 and CL n for that cohort were 20.6 ± 16.6 L, 132.0 ± 31.1 min, 3.6 ± 0.9 mL/min/kg, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…BU performed by our group were encouraging. 12 Additionally, i.v. BU administered q12 h was found to be safe and resulted in therapeutic PK ranges in adult allo-SCT recipients.…”

mentioning

confidence: 99%

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The pharmacokinetics and safety of twice daily i.v. BU during conditioning in pediatric allo-SCT recipients

Gall

Milone

Waxman

et al. 2012

Bone Marrow Transplant

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Intravenous BU divided four times daily (q6 h) has been shown to be safe and effective in pediatric allo-SCT recipients. Though less frequent dosing is desirable, pharmacokinetic (PK) data on twice daily (q12 h) i.v. BU administration in pediatric allo-SCT recipients is limited. We prospectively examined the PK results in a cohort of pediatric allo-SCT recipients receiving i.v. BU q12 h as part of conditioning before allo-SCT. BU levels were obtained after the first dose of conditioning. PK parameter analysis (n=49) yielded the following 95% confidence intervals (CI₉₅): weight-normalized volume of distribution: 0.65-0.73 L/kg; t(1/2): 122-147 min; weight-normalized clearance (CL(n)): 3.4-4.3 mL/min/kg; and area under the curve: 1835-2180 mmol × min/L. From these results, a steady state concentration was calculated with CI₉₅ between 628-746 ng/mL. Comparison between recipients ≤4 vs >4 years old revealed significant differences in t(1/2) (mean: 115 vs 146 min, P=0.008) and CL(n) (mean: 4.4 vs 3.5 mL/min/kg, P=0.038). Intravenous BU q12 h had a comparable PK to i.v. BU q6 h PK seen in the literature, and in pediatric allo-SCT recipients, is a feasible, attractive alternative to i.v. q6h dosing.

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Section: Discussionmentioning

confidence: 72%

“…BU (1077±352 mmol Â min/L). 12 When q12 h and q6 h i.v. BU AUC are converted to C ss , total BU exposure is comparable-q12 h mean C ss : 687 ng/mL vs q6 h mean C ss : 736 ng/mL.…”

Section: Discussionmentioning

confidence: 99%

“…BU PK in pediatric allo-SCT recipients. 10,12 With the same total daily dose, q12 h i.v. BU recipients have comparable V d , t 1/2 and CL n with q6 h i.v.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…BU performed by our group were encouraging. 12 Additionally, i.v. BU administered q12 h was found to be safe and resulted in therapeutic PK ranges in adult allo-SCT recipients.…”

mentioning

confidence: 99%

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