Its all about IFN‐λ4: Protective role of IFNL4 polymorphism against COVID‐19‐related pneumonia in females

Matic, Sanja; Milovanovic, Dragan; Mijailovic, Zeljko; Djurdjevic, Predrag; Sazdanovic, Predrag; Stefanovic, Srdjan; Todorovic, Danijela; Popovic, Suzana; Vitosevic, Katarina; Vukicevic, Vladimir; Vukic, Milena; Vukovic, Nenad; Milivojevic, Nevena; Zivanovic, Marko; Jakovljevic, Vladimir; Filipovic, Nenad; Djordjevic, Natasa; Baskic, Dejan

doi:10.1002/jmv.29152

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…Also, the authors observed that the likelihood of pneumonia development remained significantly associated with IFNL4 polymorphism, especially in females. These results suggest that IFNL4 rs12979860 and rs368234815 polymorphisms could predict the risk of COVID-19-related pneumonia development in females ( 23 ).…”

Section: Ifns In Sars-cov-2 Infectionmentioning

confidence: 76%

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infection

Mihaescu,

Chifiriuc,

Filip

et al. 2024

Front. Immunol.

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Mammalians sense antigenic messages from infectious agents that penetrate the respiratory and digestive epithelium, as well as signals from damaged host cells through membrane and cytosolic receptors. The transduction of these signals triggers a personalized response, depending on the nature of the stimulus and the host’s genetics, physiological condition, and comorbidities. Interferons (IFNs) are the primary effectors of the innate immune response, and their synthesis is activated in most cells within a few hours after pathogen invasion. IFNs are primarily synthesized in infected cells, but their anti-infective effect is extended to the neighboring cells by autocrine and paracrine action. The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic in 2019 was a stark reminder of the potential threat posed by newly emerging viruses. This pandemic has also triggered an overwhelming influx of research studies aiming to unveil the mechanisms of protective versus pathogenic host immune responses induced by SARS‐CoV‐2. The purpose of this review is to describe the role of IFNs as vital players in the battle against SARS‐CoV-2 infection. We will briefly characterize and classify IFNs, present the inductors of IFN synthesis, their sensors, and signaling pathways, and then discuss the role of IFNs in controlling the evolution of SARS-CoV-2 infection and its clinical outcome. Finally, we will present the perspectives and controversies regarding the prophylactic and therapeutic potential of IFNs in SARS-CoV-2 infection.

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Section: Ifns In Sars-cov-2 Infectionmentioning

confidence: 76%

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infection

Mihaescu,

Chifiriuc,

Filip

et al. 2024

Front. Immunol.

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FURIN, IFNL4, and TLR2 gene polymorphisms in relation to COVID-19 severity: a case–control study in Egyptian patients

Elgedawy,

Elabd,

Salem

et al. 2024

Infection

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Background and Aim A wide range of clinical manifestations and outcomes, including liver injury, have been reported in COVID-19 patients. We investigated the association of three substantial gene polymorphisms (FURIN, IFNL4, and TLR2) with COVID-19 disease susceptibility and severity to help predict prognosis. Methods 150 adult COVID-19-assured cases were categorized as follows: 78 patients with a non-severe presentation, 39 patients with severe disease, and 33 critically ill patients. In addition, 74 healthy controls were included. Clinical and laboratory evaluations were carried out, including complete and differential blood counts, D-dimer, lactate dehydrogenase (LDH), C-reactive protein (CRP), procalcitonin, ferritin, interleukin-6 (Il-6), and liver and kidney functions. FURIN (rs6226), IFNL4 (rs12979860), and TLR2 (rs3804099) genotyping allelic discrimination assays were conducted using real-time PCR. Results The FURIN, IFNL4, and TLR2 genotypes and their alleles differed significantly between COVID-19 patients and controls, as well as between patients with severe or critical illness and those with a non-severe presentation. According to a multivariable regression analysis, FURIN (C/T + T/T) and TLR2 (T/C + C/C) mutants were associated with COVID-19 susceptibility, with odds ratios of 3.293 and 2.839, respectively. FURIN C/C and IFNL4 T/T mutants were significantly linked to severe and critical illnesses. Multivariate regression analysis showed that FURIN (G/C + C/C) genotypes and IFNL4 T/T homozygosity were independent risk factors associated with increased mortality. Conclusion FURIN, IFNL4, and TLR2 gene variants are associated with the risk of COVID-19 occurrence as well as increased severity and poor outcomes in Egyptian patients.

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Its all about IFN‐λ4: Protective role of IFNL4 polymorphism against COVID‐19‐related pneumonia in females

Cited by 2 publications

References 47 publications

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infection

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infection

FURIN, IFNL4, and TLR2 gene polymorphisms in relation to COVID-19 severity: a case–control study in Egyptian patients

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