2001
DOI: 10.1046/j.1365-4362.2001.01039.x
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Itraconazole: an effective oral antifungal for onychomycosis

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Cited by 26 publications
(14 citation statements)
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“…ITZ is a synthetic anti-fungal drug, which is composed of a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs). Three chiral centers are present in each diastereomer which possess a molecular formula of C 35 H 38 C l2 N 8 O 4 and molecular weight of 705.64 g/mol (Grant and Clissol 1989;Jain and Sehgal 2001). ITZ is poorly soluble in aqueous media (less than 1 lg/mL in aqueous solutions at pHs of 1-12.7) with a partition coefficient [5 in octanol/water at pH 6.…”
Section: Introductionmentioning
confidence: 99%
“…ITZ is a synthetic anti-fungal drug, which is composed of a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs). Three chiral centers are present in each diastereomer which possess a molecular formula of C 35 H 38 C l2 N 8 O 4 and molecular weight of 705.64 g/mol (Grant and Clissol 1989;Jain and Sehgal 2001). ITZ is poorly soluble in aqueous media (less than 1 lg/mL in aqueous solutions at pHs of 1-12.7) with a partition coefficient [5 in octanol/water at pH 6.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] In addition, the drug has an interesting tissue distribution, which has made possible effective and rapid treatments of vaginal candidiasis when the drug is administered orally. [4][5][6] A topical itraconazole-containing formulation may be of use for several reasons including the opportunity to generate high local tissue levels, more rapid drug delivery, and lower systemic exposure.…”
Section: Introductionmentioning
confidence: 99%
“…At present, the oral antifungal agents griseofulvin (10), terbinafine (12), and itraconazole (9) are available for the treatment of tinea unguium because antifungal agents are generally ineffective when applied topically (13,23). The treatment of tinea unguium has improved following the introduction of terbinafine and itraconazole.…”
mentioning
confidence: 99%