ITGA1 (integrin, alpha 1)

Boudjadi, Salah; Beaulieu, Jean‐François

doi:10.4267/2042/62325

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…The results are shown in Figure 5. processes, such as cell differentiation, migration, survival and proliferation [19,53,54]. In fibroblasts,…”

Section: Evaluation Of Biomolecular Markers By Immunoblottingmentioning

confidence: 99%

“…Integrin alpha-1 is a transmembrane glycoprotein, which plays an important role in the adhesion of the cell to the matrix and in the transduction of the signal to the cell, regulating events such as growth, division, cell survival and apoptosis [19].…”

Section: Introductionmentioning

confidence: 99%

“…α1 is known to activate the RAS/ERK proliferative pathway and has a pro-invasive function in certain 361 cancers and it is generally considered as a stress marker [19]. Integrins are heterodimeric transmembrane glycoproteins that participate in different cell processes, such as cell differentiation, migration, survival and proliferation [19,53,54]. In fibroblasts, α1 is known to activate the RAS/ERK proliferative pathway and has a pro-invasive function in certain cancers and it is generally considered as a stress marker [19].…”

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confidence: 99%

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Antioxidant Properties of a Supercritical Fluid Extract of the Halophyte Mesembryanthemum nodiflorum L. from Sicilian Coasts: Nutraceutical and Cosmeceutical Applications

et al. 2020

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The aim of this paper was to obtain different extracts from the aerial parts of Mesembryanthemum nodiflorum, comparing traditional extraction (using solvents with increasing polarity such as hexane, ethanol 80%, acetone 70% and water) with an eco-friendly technique (supercritical fluid extraction (SFE)); to evaluate which extract showed a higher amount of antioxidants and then evaluate the bioactive properties in vitro, in human fibroblast (HS68). From the six extracts obtained it was observed that the solvent with the highest extraction efficiency was water, but the extracts in ethanol, N-hexane and SFE are those that showed the highest antioxidant activity (polyphenols, 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and reducing power). On the basis of these results, the SFE extract was chosen to evaluate the antioxidant and anti-aging activity in vitro, by assessing cell vitality and molecular markers (MTT and immunoblotting assays). The results showed that the SFE extract exerted antioxidant activity in vitro, protecting cells from mortality induced by oxidative stress; this protection was also confirmed at the molecular level, by the levels of the protein integrin -1, that is able to prevent the negative effects of a stress situation, such as oxidative stress, that could promote aging and related diseases. This extract, obtained with an eco-friendly technique, given its beneficial properties, could be used for application in nutraceuticals and cosmeceuticals.

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“…The results are shown in Figure 5. processes, such as cell differentiation, migration, survival and proliferation [19,53,54]. In fibroblasts,…”

Section: Evaluation Of Biomolecular Markers By Immunoblottingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Antioxidant Properties of a Supercritical Fluid Extract of the Halophyte Mesembryanthemum nodiflorum L. from Sicilian Coasts: Nutraceutical and Cosmeceutical Applications

et al. 2020

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Chromosome 5

2023

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Chromosome 5 presents an extensive collection of genes, and includes several cancer-associated ones. The contribution of chromosome 5 in abnormalities is evident through somatic translocations, germline, somatic, and, in some instances, expression of genes. Various syndromes are associated with chromosome 5, such as 5q minus syndrome, leading to the development of acute myeloid leukemia, PDGFRBassociated chronic eosinophilic leukemia contributing to acute myeloid leukemia, and myelodysplastic syndromes. Studies propose that a few genes on chromosome 5 play important roles withinside the increase and department of cells. When chromosome segments are deleted, as in a few instances of AML and MDS, those crucial genes are missing. Without those genes, cells can develop and divide too speedy and in an out-o- -control way. Researchers are trying to perceive the genes on chromosome five that might be associated with AML and MDS.

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ITGA1 (integrin, alpha 1)

Abstract: The α1 integrin subunit (SU) belongs to a large family of α and β subunits that are noncovalently linked to constitute αβ transmembrane units.

Cited by 2 publications

References 12 publications

Antioxidant Properties of a Supercritical Fluid Extract of the Halophyte Mesembryanthemum nodiflorum L. from Sicilian Coasts: Nutraceutical and Cosmeceutical Applications

Antioxidant Properties of a Supercritical Fluid Extract of the Halophyte Mesembryanthemum nodiflorum L. from Sicilian Coasts: Nutraceutical and Cosmeceutical Applications

Chromosome 5

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