Abstract:A numerical modeling approach was developed to simulate the propagation of shear and longitudinal sound waves in arbitrary, dense dispersions of spherical particles. The scattering interactions were modeled with vector multipole functions and boundary condition solutions for each particle. Multiple scattering was simulated by translating the scattered wave fields from one particle to another with the use of translational addition theorems, summing the multiple-scattering contributions, and recalculating the sc… Show more
“…8 The method was modified to incorporate scattering from inclusions (nuclei) within the particles (cells). A concentric core-shell structure embedded in a medium represented the cell nucleus, cell cytoplasm, and extracellular matrix, respectively.…”
Ultrasonic spectroscopy may offer an alternative to imaging methods for the in vivo detection of microscopic cancer. To investigate this potential, a numerical model that incorporates multiple scattering, wave-mode conversion, and hierarchical microstructures was developed to simulate ultrasonic interactions in biological tissue at the microscopic level. Simulated high-frequency (20–75MHz) spectra of up to 2137 cells displayed significant correlations to nucleus diameter and malignant cell infiltration, and indicated as few as 300 malignant cells may be detectable in normal tissue. The results suggest that ultrasonic spectroscopy combined with simulation-based interpretive models may provide real-time histopathology during surgeries, biopsies, and endoscopies.
“…8 The method was modified to incorporate scattering from inclusions (nuclei) within the particles (cells). A concentric core-shell structure embedded in a medium represented the cell nucleus, cell cytoplasm, and extracellular matrix, respectively.…”
Ultrasonic spectroscopy may offer an alternative to imaging methods for the in vivo detection of microscopic cancer. To investigate this potential, a numerical model that incorporates multiple scattering, wave-mode conversion, and hierarchical microstructures was developed to simulate ultrasonic interactions in biological tissue at the microscopic level. Simulated high-frequency (20–75MHz) spectra of up to 2137 cells displayed significant correlations to nucleus diameter and malignant cell infiltration, and indicated as few as 300 malignant cells may be detectable in normal tissue. The results suggest that ultrasonic spectroscopy combined with simulation-based interpretive models may provide real-time histopathology during surgeries, biopsies, and endoscopies.
“…The convergence of solutions during iterations is another limiting factor for this method. For example [24] , for longitudinal wave field at 600 kHz and for 600 µm glass beads in polymer with 30% volume fraction, numerical results do not converge after 10 iteration steps so that this method fails at this case.…”
Section: -12 Multiple Scattering By Spherical Inclusionsmentioning
confidence: 99%
“…Due to the virtual memory requirement in a computer, computation and storage of the matrix for coordinate transformation between coordinate systems of every two scatterers are limiting factors for this method [24] . The convergence of solutions during iterations is another limiting factor for this method.…”
Section: -12 Multiple Scattering By Spherical Inclusionsmentioning
confidence: 99%
“…For multiple scattering of elastic waves by spherical inclusions in arbitrary arrangement, Doyle [24] in 2006 used an iterative method (based on ordered scattering approach) for calculating wave fields in the elastic system. Calculation is carried out at each order of scattering.…”
Section: -12 Multiple Scattering By Spherical Inclusionsmentioning
A computational system is built for conducting deterministic simulations of threedimensional multiple scattering of elastic waves by spherical inclusions.Based on expansion expression of elastic wave fields in terms of scalar and vector spherical harmonics, analytically exact solutions of single scattering and multiple scattering are obtained, implemented and verified. The verification is done by using continuities of displacement and surface traction at the interface between an inclusion and host medium, energy conservation and published results.The scatterer polymerization methodology is extended to three-dimensional multiple scattering solution. By using this methodology, an assemblage of actual scatterers can be treated as an abstract scatterer. This methodology is verified by using different approaches, with or without scatterer polymerization, to solve a physically the same multiple scattering problem.As an application example, band gap formation process for elastic wave propagation in cubic lattice arrangements of spherical scatterers is observed through a series of numerical simulations. Along the direction of the incident wave, scatterer arrangements are viewed as comprising layers of scatterers, within which scatterers form a square grid. Starting from one layer and by increasing the number of layers, near-field forward wave propagation spectra are computed as the number of layers increases.These simulations also demonstrates that the computational system has the capability to simulate multiple scattering solutions of elastic waves in three-dimension. The scatterer polymerization methodology is extended to three-dimensional multiple scattering solution. By using this methodology, an assemblage of actual scatterers can be treated as an abstract scatterer. This methodology is verified by using different approaches, with or without scatterer polymerization, to solve a physically the same multiple scattering problem.As an application example, band gap formation process for elastic wave propagation in cubic lattice arrangements of spherical scatterers is observed through a series of numerical simulations. Along the direction of the incident wave, scatterer arrangements are viewed as comprising layers of scatterers, within which scatterers form a square grid. Starting from one layer and by increasing the number of layers, near-field forward wave propagation spectra are computed as the number of layers increases.These simulations also demonstrates that the computational system has the capability to simulate multiple scattering solutions of elastic waves in three-dimension.
“…A metodologia seguida para a construção da matriz T de uma inclusão esférica simples é similar à reportada em [30][31][32], já a matriz T para a inclusão esférica multi-revestida será uma extensão das reportadas em [16,50]. …”
Section: Espalhamento Por Uma Inclusão Esférica: Matriz Tunclassified
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.