Iterative reconstruction for snapshot intensity-modulated linear imaging spectropolarimetry without Fourier transform and phase calibration

Snapshot polarized light scattering spectroscopy using spectrally‐modulated polarimetry for early gastric cancer detection

“…Traditionally, the FTM was used to extract the spectra of Stokes parameters in the Fourier frequency domain [35]. However, the recovered spectral resolution is usually three times lower than the intrinsic spectral resolution of the used spectrometer [37,39,45]. However, the accurate inference of the morphological information of cell nuclei requires the spectra of the single scattering light with a relatively high spectral resolution.…”

“…Therefore, the FTM with a low spectral resolution is not suitable for inferring the morphological information. In contrast, our proposed CSIM has the capability of retaining the intrinsic resolution of the used spectrometer [39]. This function is very vital for the use of the PLSS to infer morphological information.…”

“…However, the state-of-the-art reconstruction method, Fourier transform method (FTM) [34][35][36][37][38], uses the Fourier transform to extract the Stokes parameters from the modulated spectrum in the frequency domain [35]. Although straightforward, FTM still has a series of problems such as channel cross-talk, highfrequency loss, and the need for phase calibration [37,[39][40][41], especially the reconstructed spectral resolution is lower than the used spectrometer, which makes the FTM unsuitable to the PLSS, and requires a relatively high spectral resolution. In order to overcome these problems, a novel reconstruction method called continuous slide iterative method (CSIM) was proposed by our group [39].…”

“…Although straightforward, FTM still has a series of problems such as channel cross-talk, highfrequency loss, and the need for phase calibration [37,[39][40][41], especially the reconstructed spectral resolution is lower than the used spectrometer, which makes the FTM unsuitable to the PLSS, and requires a relatively high spectral resolution. In order to overcome these problems, a novel reconstruction method called continuous slide iterative method (CSIM) was proposed by our group [39]. The key advantage of the CSIM is that the recovered spectral resolution is very close to the inherent resolution of the used spectrometer.…”

“…This function is very vital for using PLSS to infer morphological information. However, the CSIM was just verified using the non-imaging spectrometer on the three virtual spatial points [39]. It has not yet been used and verified by a practical detection system.…”